Nonspecific airway hyperresponsiveness induced by inhalation exposure to sulfuric acid aerosol: an in vitro assessment.
Nonspecific airway hyperresponsiveness induced by inhalation exposure to sulfuric acid aerosol: an in vitro assessment.
复制标题
吸入暴露于硫酸气溶胶引起的非特异性气道高反应性：体外评估。
DOI：
10.1006/taap.1994.1050
复制
发表时间：
1994
影响因子：
3.8
通讯作者：
Schlesinger,RB
中科院分区：
文献类型：
--
作者：
el-Fawal,HA;Schlesinger,RB
空气污染可能是最近哮喘严重程度和患病率增加的一个因素，但环境污染物混合物中可能造成的具体化学成分尚未确定。酸性硫酸盐气溶胶，例如硫酸，与哮喘患者症状的恶化以及正常实验动物中非特异性气道高反应性的诱导有关。本研究检验了单次（3 小时）吸入硫酸对健康兔子诱导非特异性气道高反应性的能力。使用体外测定评估反应性，该测定涉及向暴露于 50-500 μg/m(3) 硫酸气溶胶的动物获得的支气管和气管环施用递增剂量的乙酰胆碱或组胺。暴露于≥75 μg/m(3) 后，注意到对两种激动剂的支气管高反应性。此外，硫酸改变了气管对组胺的正常反应模式。这些结果进一步支持了酸性硫酸盐在诱导气道高反应性中的作用，并表明这种作用可能是由于调节了参与维持气道张力的药理受体。
Air pollution may be a factor in the recent increase in severity and prevalence of asthma, but the specific chemical components within the ambient pollutant mix which may be responsible have not been delineated. Acid sulfate aerosols, such as sulfuric acid, have been associated with exacerbation of symptoms in asthmatics and induction of nonspecific airway hyperresponsiveness in normal laboratory animals. This study examined the ability of single (3 hr) inhalation exposures to sulfuric acid to induce nonspecific airway hyperresponsiveness in healthy rabbits. Responsiveness was assessed using an in vitro assay involving administration of increasing doses of acetylcholine or histamine to bronchial and tracheal rings obtained from animals exposed to 50-500 μg/m(3) sulfuric acid aerosol. Bronchial hyperresponsiveness to both agonists was noted following exposures at ≥75 μg/m(3). In addition, sulfuric acid altered the normal response pattern of trachea to histamine. The results provide further support for a role of acid sulfates in the induction of airway hyperresponsiveness, and suggest that effects may be due to modulation of pharmacological receptors involved in maintaining airway tone.