A cry in the dark: depressed mothers show reduced neural activation to their own infant's cry
A cry in the dark: depressed mothers show reduced neural activation to their own infant's cry
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DOI：
10.1093/scan/nsq091
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发表时间：
2012-02-01
影响因子：
4.2
通讯作者：
Ablow, Jennifer C.
中科院分区：
文献类型：
--
作者：
Laurent, Heidemarie K.;Ablow, Jennifer C.
这项研究调查了初产母亲对其婴儿的痛苦信号的神经反应与抑郁症相关的差异。在功能神经影像检查中，被诊断患有重度抑郁症的母亲 (n = 11) 和没有可诊断精神病理学的母亲 (n = 11) 暴露于自己 18 个月大婴儿的哭声以及不熟悉的婴儿哭声和控制声音。与非抑郁母亲的整个大脑反应相比，抑郁母亲对自己婴儿哭声的反应大于其他声音[错误发现率（FDR）已纠正]。还测试了自我报告抑郁症状（CESD）的连续测量作为母亲反应的预测因素。在旁/边缘和前额叶区域的分布式网络中，非抑郁的母亲对自己婴儿的哭声的激活程度高于控制声音，而抑郁的母亲作为一个群体则没有表现出激活。与抑郁的母亲相比，非抑郁的母亲表现出明显更强的纹状体（尾状核、伏隔核）和内侧丘脑激活。此外，抑郁症状较低的母亲在左眼眶额叶、背侧前扣带回和内侧上额叶区域的激活更强烈。与抑郁的母亲相比，非抑郁的母亲在枕叶梭形区域对自己的婴儿的哭声比其他婴儿的哭声更大。这些涉及情绪反应和调节的神经网络的紊乱可能有助于解释抑郁母亲的养育缺陷。
This study investigated depression-related differences in primiparous mothers' neural response to their own infant's distress cues. Mothers diagnosed with major depressive disorder (n = 11) and comparison mothers with no diagnosable psychopathology (n = 11) were exposed to their own 18-months-old infant's cry sound, as well as unfamiliar infant's cry and control sound, during functional neuroimaging. Depressed mothers' response to own infant cry greater than other sounds was compared to non-depressed mothers' response in the whole brain [false discovery rate (FDR) corrected]. A continuous measure of self-reported depressive symptoms (CESD) was also tested as a predictor of maternal response. Non-depressed mothers activated to their own infant's cry greater than control sound in a distributed network of para/limbic and prefrontal regions, whereas depressed mothers as a group failed to show activation. Non-depressed compared to depressed mothers showed significantly greater striatal (caudate, nucleus accumbens) and medial thalamic activation. Additionally, mothers with lower depressive symptoms activated more strongly in left orbitofrontal, dorsal anterior cingulate and medial superior frontal regions. Non-depressed compared to depressed mothers activated uniquely to own infant greater than other infant cry in occipital fusiform areas. Disturbance of these neural networks involved in emotional response and regulation may help to explain parenting deficits in depressed mothers.