Comprehensive Profile of Cardiopulmonary Exercise Testing in Ambulatory Persons with Multiple Sclerosis
Comprehensive Profile of Cardiopulmonary Exercise Testing in Ambulatory Persons with Multiple Sclerosis
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DOI：
10.1007/s40279-016-0472-6
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发表时间：
2016-09-01
期刊：
影响因子：
9.8
通讯作者：
Motl, Robert W.
中科院分区：
文献类型：
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作者：
Klaren, Rachel E.;Sandroff, Brian M.;Motl, Robert W.
运动在多发性硬化症（MS）中的研究和应用通常需要心肺运动试验（CPET）来提供运动耐量和反应的综合评估，包括肺、心血管和骨骼肌系统的评估。在MS患者中进行的CPET研究具有相当大的局限性，包括样本量小，通常没有对照;未报告残疾状态的结果;以及不同研究中的运动测试模式不同。尽管已经在MS患者中研究了CPET的一些关键结局变量，目的本研究的目的是提供一个全面的检查结果变量从CPET与MS和健康对照组。方法我们包括数据从162人MS和80名健康对照者进行CPET腿功计和满足标准的有效用于测量摄氧量（VO 2）、二氧化碳产生量（VCO 2）、通气量（VE）、呼吸交换率、工作率和心率（HR）的测试。使用标准指南处理计算的变量[即无氧阈（VO 2/VCO 2）、VE/VCO 2斜率、VO 2/功率斜率、VO 2/HR斜率和摄氧效率斜率]。我们检查了组间CPET变量的差异（例如MS与对照组和轻度、中度和重度残疾状态的类别）使用协方差分析（ANCOVA），控制年龄、性别、体重指数和疾病持续时间。结论我们的研究结果为MS患者CPET的评估提供了新的信息，可用于制定运动处方和记录基于综合变量的运动训练适应性在CPET期间。
Background The study and application of exercise in multiple sclerosis (MS) often requires cardiopulmonary exercise testing (CPET) to provide a comprehensive assessment of exercise tolerance and responses, including an evaluation of the pulmonary, cardiovascular, and skeletal muscle systems. Research on CPET in persons with MS has considerable limitations, including small sample sizes, often without controls; not reporting outcomes across disability status; and different modalities of exercise testing across studies. Although some key outcome variables of CPET have been studied in persons with MS, additional calculated variables have not been directly studied.Objective The objective of this study was to provide a comprehensive examination of outcome variables from CPET among persons with MS and healthy controls.Methods We included data from 162 persons with MS and 80 healthy controls who underwent CPET on a leg ergometer and satisfied criteria for valid testing for measuring oxygen uptake (VO2), carbon dioxide production (VCO2), ventilation (VE), respiratory exchange ratio, work rate, and heart rate (HR). Calculated variables [i.e. ventilatory anaerobic threshold (VO2/VCO2), VE/VCO2 slope, VO2/power slope, VO2/HR slope, and oxygen uptake efficiency slope] were processed using standard guidelines. We examined differences in the CPET variables between groups (e.g. MS vs. controls and categories of mild, moderate, and severe disability status) using analysis of covariance (ANCOVA), controlling for age, sex, body mass index, and disease duration.Results Overall, persons with MS demonstrate alterations in outcomes from CPET compared with controls, and these are generally exacerbated with increasing disability.Conclusion Our results provide novel information for the evaluation of CPET in MS for developing exercise prescriptions and documenting adaptations with exercise training based on the comprehensive variables obtained during CPET.