The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation provides a better definition of cardiovascular burden associated with CKD than the Modification of Diet in Renal Disease (MDRD) Study formula in subjects with type 2 diabetes
The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation provides a better definition of cardiovascular burden associated with CKD than the Modification of Diet in Renal Disease (MDRD) Study formula in subjects with type 2 diabetes
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DOI：
10.1016/j.atherosclerosis.2011.04.035
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发表时间：
2011-09-01
期刊：
影响因子：
5.3
通讯作者：
Penno, Giuseppe
中科院分区：
文献类型：
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作者：
Pugliese, Giuseppe;Solini, Anna;Penno, Giuseppe
目的：慢性肾脏病（CKD）-流行病学协作组（EPI）公式被证明比肾脏病饮食改良（MDRD）研究公式更准确地估计一般人群的肾小球滤过率（GFR）。本研究旨在评估2型糖尿病患者CKD相关的心血管疾病（CVD）负担，使用这两个GFR估算公式定义CKD。方法：这项队列研究检查了15名，773例参与肾功能不全和心血管事件意大利多中心研究的2型糖尿病白人患者（NCT 00715481），并在2007-2008年参加19个糖尿病诊所的基线访视。采用改良Jaffe法测定血清肌酐。尿蛋白测定采用免疫比浊法或免疫比浊法。CKD定义为估计的GFR（eGFR）
Objective: The chronic kidney disease (CKD)-Epidemiology Collaboration (EPI) equation was shown to be more accurate than the Modification of Diet in Renal Disease (MDRD) Study formula for estimating glomerular filtration rate (GFR) in the general population. This study was aimed at assessing cardiovascular disease (CVD) burden associated with CKD in type 2 diabetes, using these two GFR estimating formulas for CKD definition.Methods: This cohort study examined 15,773 Caucasian patients with type 2 diabetes participating in the Renal Insufficiency And Cardiovascular Events Italian Multicenter Study (NCT00715481) and attending the baseline visit in 19 diabetes clinics in years 2007-2008. Serum creatinine was assessed by the modified Jaffe method. Albuminuria was measured by immunonephelometry or immunoturbidimetry. CKD was defined as an estimated GFR (eGFR)