The PIN auxin efflux facilitator network controls growth and patterning in Arabidopsis roots
The PIN auxin efflux facilitator network controls growth and patterning in Arabidopsis roots
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DOI：
10.1038/nature03184
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发表时间：
2005-01-06
期刊：
影响因子：
64.8
通讯作者：
Scheres, B
中科院分区：
文献类型：
--
作者：
Blilou, I;Xu, J;Scheres, B
植物生长调节剂生长素的局部积累介导拟南芥根的模式形成，并影响侧根和茎源原基的生长和发育。然而，目前还不清楚生长素如何能够同时调节模式和器官生长，以及它的分布是如何稳定在一个原基特异性的方式。在这里，我们表明，五个PIN基因共同控制生长素的分布，以调节细胞分裂和细胞扩张的主根。此外，这些基因的联合行动有一个重要的作用，通过集中生长素最大和限制的表达域的PLETHORA（PLT）基因，主要决定因素的根干细胞规格的图案形成。反过来，PLT基因是PIN基因转录所必需的，以稳定远端根尖处的生长素最大值。我们的数据揭示了生长素运输促进剂和根命运决定因素的相互作用网络，控制图案和根原基的生长。
Local accumulation of the plant growth regulator auxin mediates pattern formation in Arabidopsis roots and influences outgrowth and development of lateral root- and shoot-derived primordia. However, it has remained unclear how auxin can simultaneously regulate patterning and organ outgrowth and how its distribution is stabilized in a primordium-specific manner. Here we show that five PIN genes collectively control auxin distribution to regulate cell division and cell expansion in the primary root. Furthermore, the joint action of these genes has an important role in pattern formation by focusing the auxin maximum and restricting the expression domain of PLETHORA (PLT) genes, major determinants for root stem cell specification. In turn, PLT genes are required for PIN gene transcription to stabilize the auxin maximum at the distal root tip. Our data reveal an interaction network of auxin transport facilitators and root fate determinants that control patterning and growth of the root primordium.