Statistical localization of human olfactory cortex
Statistical localization of human olfactory cortex
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DOI：
10.1016/j.neuroimage.2012.10.030
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发表时间：
2013-02-01
期刊：
影响因子：
5.7
通讯作者：
Lundstroem, Johan N.
中科院分区：
文献类型：
--
作者：
Seubert, Janina;Freiherr, Jessica;Lundstroem, Johan N.
在过去的几十年中，功能神经影像学方法已被广泛用于探索嗅觉加工的神经基质。虽然对嗅觉皮层的功能解剖学的普遍共识开始出现，个别处理节点的功能背后的机制仍然存在争议。此外，目前还不清楚在何种程度上不同的调查结果是由方法上的差异造成的。使用激活似然估计（ALE），本研究的目的是统计学联合收割机所有已发表的数据嗅觉功能神经成像提供一个概率图，反映该领域的状态。此外，我们根据各种方法学方法对研究进行分组，以调查这些方法是否系统地影响了报告的结果。共有45项研究（69项对比，594个病灶）符合我们的纳入标准。在通常标记为初级和次级嗅觉皮层的区域中观察到气味相对于基线的显著ALE峰，例如梨状和眶额皮层、杏仁核、前额叶和腹侧壳核。此外，不同的方法能够在嗅觉网络的这些不同节点中诱导激活的程度也存在差异。(C)2012 Elsevier Inc. All rights reserved.
Functional neuroimaging methods have been used extensively during the last decades to explore the neural substrates of olfactory processing. While a general consensus on the functional anatomy of olfactory cortex is beginning to emerge, the mechanisms behind the functions of individual processing nodes still remain debated. Further, it remains unclear to which extent divergent findings result from differences in methodological approaches. Using Activation Likelihood Estimation (ALE), the aim of the present study was to statistically combine all published data on functional neuroimaging of olfaction to provide a probability map reflecting the state of the field to date. Additionally, we grouped studies according to various methodological approaches to investigate whether these systematically affected the reported findings. A total of 45 studies (69 contrasts, 594 foci) met our inclusion criteria. Significant ALE peaks for odor against baseline were observed in areas commonly labeled as primary and secondary olfactory cortex, such as the piriform and orbitofrontal cortex, amygdala, anterior insula, and ventral putamen. In addition, differences were observed in the extent to which different methods were able to induce activation in these different nodes of the olfactory network. (C) 2012 Elsevier Inc. All rights reserved.