Human γδT-cell subsets and their involvement in tumor immunity.
Human γδT-cell subsets and their involvement in tumor immunity.
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人类 γ δ T 细胞亚群及其在肿瘤免疫中的作用
DOI：
10.1038/cmi.2016.55
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发表时间：
2017-03
影响因子：
24.1
通讯作者：
Huang J
中科院分区：
文献类型：
--
作者：
Wu D;Wu P;Qiu F;Wei Q;Huang J
γδT细胞是先天性淋巴细胞的保守群体，具有不同的结构和功能异质性，其在肿瘤进展期间参与各种免疫应答。γδT细胞通过发挥直接细胞毒性、强细胞因子产生和间接抗肿瘤免疫应答来执行有效的免疫监视。然而，某些γδ T细胞亚群也通过促进癌症相关炎症和免疫抑制而促进肿瘤进展。在这里，我们回顾了最近的观察有关的抗肿瘤和促肿瘤作用的人γδT细胞的主要结构和功能的子集，描述这些子集是如何被激活和极化，以及这些事件如何与随后的功能在肿瘤免疫。这些研究提供了对γδ T细胞功能的操纵的见解，以促进肿瘤治疗的更有针对性的方法。
γδT cells are a conserved population of innate lymphocytes with diverse structural and functional heterogeneity that participate in various immune responses during tumor progression. γδT cells perform potent immunosurveillance by exerting direct cytotoxicity, strong cytokine production and indirect antitumor immune responses. However, certain γδT-cell subsets also contribute to tumor progression by facilitating cancer-related inflammation and immunosuppression. Here, we review recent observations regarding the antitumor and protumor roles of major structural and functional subsets of human γδT cells, describing how these subsets are activated and polarized, and how these events relate to subsequent function in tumor immunity. These studies provide insights into the manipulation of γδT-cell function to facilitate more targeted approaches for tumor therapy.