Changes in synaptic markers after administration of ketamine or psychedelics: a systematic scoping review.
Changes in synaptic markers after administration of ketamine or psychedelics: a systematic scoping review.
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DOI：
10.3389/fpsyt.2023.1197890
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发表时间：
2023
影响因子：
4.7
通讯作者：
Angarita, Gustavo A.
中科院分区：
文献类型：
--
作者：
Zhornitsky, Simon;Oliva, Henrique N. P.;Jayne, Laura A.;Allsop, Aza S. A.;Kaye, Alfred P.;Potenza, Marc N.;Angarita, Gustavo A.
克他命和致幻剂有滥用倾向。它们还可以诱导“变革性体验”，使个人体验到增强的意识状态。这种增强的意识可以导致预先存在的行为模式的变化，这可能有利于治疗物质使用障碍（SUD）。临床前和临床研究表明，氯胺酮和致幻剂可能会改变与突触密度相关的标志物，这些变化可能是致敏、条件性位置偏爱、自我给药和言语记忆表现等效应的基础。在这篇范围审查中，我们检查了暴露于氯胺酮和/或致幻剂后测量动物和人类突触标志物的研究。根据PRISMA指南，通过PubMed、EBSCO、Scopus和Web of Science，基于已发表的方案（开放科学框架，DOI：10.17605/OSF.IO/4309）进行系统检索。包括体内和体外研究。对以下突触标志物的研究包括：树突结构变化、PSD-95、突触蛋白-1、突触素-1、突触结合蛋白-1和SV 2A。最终分析中纳入了84项研究。71项研究检查了氯胺酮治疗后的突触标记物，9项研究了致幻剂，4项研究了两者。致幻剂包括裸盖菇素/裸盖菇素、麦角酸二乙胺、N，N-二甲基色胺、2，5-二甲氧基-4-碘苯丙胺和伊波替尼/诺波替尼。在基础条件下单次给予氯胺酮时，报告了海马和前额叶皮质（PFC）突触变化的混合结果。在使用氯胺酮重复给药的研究中，在基础条件下观察到类似的混合结果。然而，在压力条件下对动物进行检查的研究发现，单剂量氯胺酮抵消了海马和PFC中突触标记物的压力相关减少。重复给予氯胺酮也抵消了海马中的压力效应。迷幻药通常会增加突触标记，但某些药物的结果更一致。氯胺酮和致幻剂在某些条件下可以增加突触标记。异质性结果可能与方法学差异、给予的药物（或相同药物的不同制剂）、性别和标志物类型有关。未来的研究可以通过使用荟萃分析方法或更充分考虑个体差异的研究设计来解决看似混合的结果。
Ketamine and psychedelics have abuse liability. They can also induce “transformative experiences” where individuals experience enhanced states of awareness. This enhanced awareness can lead to changes in preexisting behavioral patterns which could be beneficial in the treatment of substance use disorders (SUDs). Preclinical and clinical studies suggest that ketamine and psychedelics may alter markers associated with synaptic density, and that these changes may underlie effects such as sensitization, conditioned place preference, drug self-administration, and verbal memory performance. In this scoping review, we examined studies that measured synaptic markers in animals and humans after exposure to ketamine and/or psychedelics. A systematic search was conducted following PRISMA guidelines, through PubMed, EBSCO, Scopus, and Web of Science, based on a published protocol (Open Science Framework, DOI: 10.17605/OSF.IO/43FQ9). Both in vivo and in vitro studies were included. Studies on the following synaptic markers were included: dendritic structural changes, PSD-95, synapsin-1, synaptophysin-1, synaptotagmin-1, and SV2A. Eighty-four studies were included in the final analyses. Seventy-one studies examined synaptic markers following ketamine treatment, nine examined psychedelics, and four examined both. Psychedelics included psilocybin/psilocin, lysergic acid diethylamide, N,N-dimethyltryptamine, 2,5-dimethoxy-4-iodoamphetamine, and ibogaine/noribogaine. Mixed findings regarding synaptic changes in the hippocampus and prefrontal cortex (PFC) have been reported when ketamine was administered in a single dose under basal conditions. Similar mixed findings were seen under basal conditions in studies that used repeated administration of ketamine. However, studies that examined animals during stressful conditions found that a single dose of ketamine counteracted stress-related reductions in synaptic markers in the hippocampus and PFC. Repeated administration of ketamine also counteracted stress effects in the hippocampus. Psychedelics generally increased synaptic markers, but results were more consistently positive for certain agents. Ketamine and psychedelics can increase synaptic markers under certain conditions. Heterogeneous findings may relate to methodological differences, agents administered (or different formulations of the same agent), sex, and type of markers. Future studies could address seemingly mixed results by using meta-analytical approaches or study designs that more fully consider individual differences.
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影响因子：
13.5
作者：
Abdallah CG;Sanacora G;Duman RS;Krystal JH
通讯作者：
Krystal JH
影响因子：
11
作者：
D'Souza, Deepak Cyril;Radhakrishnan, Rajiv;Skosnik, Patrick
通讯作者：
Skosnik, Patrick
影响因子：
64.8
作者：
Cameron LP;Tombari RJ;Lu J;Pell AJ;Hurley ZQ;Ehinger Y;Vargas MV;McCarroll MN;Taylor JC;Myers-Turnbull D;Liu T;Yaghoobi B;Laskowski LJ;Anderson EI;Zhang G;Viswanathan J;Brown BM;Tjia M;Dunlap LE;Rabow ZT;Fiehn O;Wulff H;McCorvy JD;Lein PJ;Kokel D;Ron D;Peters J;Zuo Y;Olson DE
通讯作者：
Olson DE
影响因子：
5.3
作者：
Camargo, Anderson;Dalmagro, Ana Paula;Rodrigues, Ana Lucia S.
通讯作者：
Rodrigues, Ana Lucia S.
DOI：
10.1073/pnas.1517045112
发表时间：
2015-12-15
影响因子：
11.1
作者：
Chen, Xiaobing;Levy, Jonathan M.;Reese, Thomas S.
通讯作者：
Reese, Thomas S.