Smad10 is required for formation of the frog nervous system.
Smad10 is required for formation of the frog nervous system.
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DOI：
10.1016/s1534-5807(02)00172-7
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发表时间：
2002-06
影响因子：
11.8
通讯作者：
J. LeSueur;E. S. Fortuno;R. McKay;J. Graff
中科院分区：
文献类型：
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作者：
J. LeSueur;E. S. Fortuno;R. McKay;J. Graff
在神经系统建立其复杂的细胞类型和连接阵列之前，多能细胞被指示采用神经命运，并建立了前后模式。在这份报告中，我们证明了Smad10是转化生长因子β信号的细胞内转导蛋白家族的成员，是神经系统形成所必需的。此外，两种被认为是神经诱导和模式形成关键的分子，骨形态发生蛋白(BMP)拮抗剂和成纤维细胞生长因子(FGF)，需要Smad10来进行这些活动。这些数据表明，Smad10可能是青蛙神经系统发育的中心调节因子。
Before the nervous system establishes its complex array of cell types and connections, multipotent cells are instructed to adopt a neural fate and an anterior-posterior pattern is established. In this report, we show that Smad10, a member of the Smad family of intracellular transducers of TGFβ signaling, is required for formation of the nervous system. In addition, two types of molecules proposed as key to neural induction and patterning, bone morphogenetic protein (BMP) antagonists and fibroblast growth factor (FGF), require Smad10 for these activities. These data suggest that Smad10 may be a central mediator of the development of the frog nervous system.