Complement Receptor 1: disease associations and therapeutic implications.

Complement Receptor 1: disease associations and therapeutic implications.
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DOI:
10.1016/j.molimm.2008.09.026
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发表时间:
2009-03
影响因子:
3.6
通讯作者:
Das N
Das N
中科院分区:
医学3区
文献类型:
--
作者:
Khera R;Das N

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过度的补体激活在一系列自身免疫性和炎症性疾病的发病机制中是一个关键事件。补体受体1(CR1)是一种研究此类疾病的易感性、病理生理学、诊断、预后和治疗的分子。本文对CR1的结构、功能、遗传学、疾病相关性和治疗意义的研究现状进行了综述。
Exaggerated complement activation is a key event in the pathogenesis of a range of autoimmune and inflammatory diseases. Complement Receptor 1 (CR1) has emerged as a molecule of immense interest in gaining insight to the susceptibility, pathophysiology, diagnosis, prognosis and therapy of such diseases. This review brings forth a composite view of the current understanding on the structure, functions, genetics, disease associations and therapeutic implications of CR1.
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