Current progress in the development of a prophylactic vaccine for HIV-1.
Current progress in the development of a prophylactic vaccine for HIV-1.
复制标题
DOI：
10.2147/dddt.s6959
复制
发表时间：
2010-12-22
期刊：
影响因子：
--
通讯作者：
Matthews QL
中科院分区：
文献类型：
--
作者：
Gamble LJ;Matthews QL
自从 20 世纪 80 年代初发现并定性为一种攻击免疫系统的病毒以来，人类免疫缺陷病毒 1 (HIV-1) 感染的治疗已取得了一些成功。然而，由于这种病毒对公共卫生造成巨大影响，迫切需要疫苗。尽管科学家和临床医生不懈努力，仍然没有安全有效的疫苗能够提供绝育免疫力。提供针对艾滋病毒感染的绝育免疫力的疫苗仍然难以捉摸，部分原因如下：1）病毒的多样性程度，2）病毒逃避宿主免疫力的能力，以及3）缺乏合适的动物模型来测试候选疫苗。人们已经进行了多次尝试来刺激免疫系统以提供针对艾滋病毒感染的保护。在这里，我们将讨论诱导绝育性免疫的尝试，包括传统的疫苗接种尝试、诱导广泛中和抗体的产生、DNA 疫苗和病毒载体的使用。其中一些尝试显示出有待继续研究工作的希望。
Since its discovery and characterization in the early 1980s as a virus that attacks the immune system, there has been some success for the treatment of human immunodeficiency virus-1 (HIV-1) infection. However, due to the overwhelming public health impact of this virus, a vaccine is needed urgently. Despite the tireless efforts of scientist and clinicians, there is still no safe and effective vaccine that provides sterilizing immunity. A vaccine that provides sterilizing immunity against HIV infection remains elusive in part due to the following reasons: 1) degree of diversity of the virus, 2) ability of the virus to evade the hosts’ immunity, and 3) lack of appropriate animal models in which to test vaccine candidates. There have been several attempts to stimulate the immune system to provide protection against HIV-infection. Here, we will discuss attempts that have been made to induce sterilizing immunity, including traditional vaccination attempts, induction of broadly neutralizing antibody production, DNA vaccines, and use of viral vectors. Some of these attempts show promise pending continued research efforts.