Cardiotoxicity of Anticancer Therapeutics.
Cardiotoxicity of Anticancer Therapeutics.
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DOI：
10.3389/fcvm.2018.00009
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发表时间：
2018
影响因子：
3.6
通讯作者：
Chen H
中科院分区：
文献类型：
--
作者：
Dong J;Chen H
随着癌症治疗的不断改进和进步，与抗癌治疗相关的不良副作用也引起了更多的关注，并已被广泛探索。因此，治疗后后续行动的重要性越来越与讨论相关。当代的治疗方法，如酪氨酸激酶抑制剂、蒽环类化疗和免疫治疗方案在治疗不同形式的癌症中是有效的;然而，这些试剂通过干扰DNA复制或阻止DNA修复而起作用，引起内皮功能障碍，产生活性氧或引发非特异性免疫应答。因此，治疗后出现心脏毒性作用，如高血压、心力衰竭和左心室功能障碍。对心血管并发症的认识不断提高，导致人们对治疗策略的演变给予了细致的关注，并在增强治疗有效性和最大限度地减少对心血管系统的不良毒性之间进行了仔细监测，其中心理评估，早期检测方法，如生物标志物，磁共振成像，各种逆转心脏毒性事件损害的药物越来越普遍，其重要性也大大增加。充分了解风险因素对接受癌症治疗的各种患者的作用机制，也越来越普遍地预防心脏毒性。
As cancer therapeutics continues to improve and progress, the adverse side effects associated with anticancer treatments have also attracted more attention and have become extensively explored. Consequently, the importance of posttreatment follow-ups is becoming increasingly relevant to the discussion. Contemporary treatment methods, such as tyrosine kinase inhibitors, anthracycline chemotherapy, and immunotherapy regimens are effective in treating different modalities of cancers; however, these reagents act through interference with DNA replication or prevent DNA repair, causing endothelial dysfunction, generating reactive oxygen species, or eliciting non-specific immune responses. Therefore, cardiotoxic effects, such as hypertension, heart failure, and left ventricular dysfunction, arise posttreatment. Rising awareness of cardiovascular complications has led to meticulous attention for the evolution of treatment strategies and carefully monitoring between enhanced treatment effectiveness and minimization of adverse toxicity to the cardiovasculature, in which psychological assessments, early detection methods such as biomarkers, magnetic resonance imaging, and various drugs to reverse the damage from cardiotoxic events are more prevalent and their emphasis has increased tremendously. Fully understanding the mechanisms by which the risk factors action for various patients undergoing cancer treatment is also becoming more prevalent in preventing cardiotoxicity down the line.