A biomimicking and electrostatic self-assembly strategy for the preparation of glycopolymer decorated photoactive nanoparticles
A biomimicking and electrostatic self-assembly strategy for the preparation of glycopolymer decorated photoactive nanoparticles
复制标题
用于制备糖聚合物修饰光活性纳米粒子的仿生和静电自组装策略
DOI：
10.1039/c6py00129g
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发表时间：
2016-01-01
影响因子：
4.6
通讯作者：
Chen, Gaojian
中科院分区：
文献类型：
--
作者：
Chen, Kui;Bao, Meimei;Chen, Gaojian
合成了新型可控共聚物PDMA-co-PDMAEMA（含生物激发的多巴胺链段和正电性PDMAEMA链段）、PMAG-b-PMAA（含生物靶向的葡萄糖链段和负电性PMAA链段）和羧基封端的PMAG均聚物，并通过NMR、GPC、DLS和zeta电位测量进行了研究。将含多巴胺的聚合物与酞菁锌（ZnPc）自组装后，再用糖聚合物PMAG-b-PMAA修饰，最终得到的纳米粒子具有更好的血清稳定性和单线态氧量子产率。更重要的是，体外和体内PDT实验表明，预先设计的光活性纳米颗粒可以很好地抑制肿瘤细胞的生长。
Novel and well-controlled copolymers, PDMA-co-PDMAEMA with bio-inspired dopamine-containing segments and electropositive PDMAEMA segments, PMAG-b-PMAA consisting of bio-targeted glucose-containing segments and electronegative PMAA segments, and a carboxyl-ending PMAG homopolymer, were synthesized and investigated by a combination of NMR, GPC, DLS and zeta potential measurements. After self-assembling the dopamine-containing polymer with Zn phthalocyanine (ZnPc) and decorating it with the sugar polymer PMAG-b-PMAA, the final nanoparticles presented better serum-stability and singlet oxygen quantum yields. More importantly, the in vitro and in vivo PDT experiments indicated that the pre-designed photoactive nanoparticles can well inhibit the growth of tumor cells.