Acute fulminant intravascular hemolysis induced by Clostridium perfringens in a symptomatic multiple myeloma patient under immuno-chemotherapy
Acute fulminant intravascular hemolysis induced by Clostridium perfringens in a symptomatic multiple myeloma patient under immuno-chemotherapy
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免疫化疗下有症状的多发性骨髓瘤患者产气荚膜梭菌引起的急性暴发性血管内溶血
DOI：
10.1007/s00277-022-05010-7
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发表时间：
2022
影响因子：
3.5
通讯作者：
Tomita Akihiro
中科院分区：
文献类型：
--
作者：
Yamamoto Hideyuki;Mizutani Yuki;Iriyama Chisako;Goto Naoe;Okamoto Akinao;Kato Toshiharu;Shintani Chiyo;Yamamoto Naoki;Miyama Takahiko;Mihara Keichiro;Okamoto Masataka;Tomita Akihiro
Welch氏杆菌是一种形成孢子的厌氧细菌，已知会引起食物中毒和气性坏疽[1]。在免疫功能低下的患者中，C.据报道，产气荚膜杆菌感染可在短时间内引起非创伤性气性坏疽、严重溶血和死亡[2-4]。然而，在血液系统恶性肿瘤病例中，特别是多发性骨髓瘤（MM），关于这种感染的信息非常有限。在此，我们报告一个多发性骨髓瘤病人并发急性严重血管内溶血，由于C。产气荚膜杆菌败血症，患者在靶向治疗（包括免疫调节药物和抗CD 38单克隆抗体治疗）后的挽救化疗期间症状发作后4小时内死亡。
Welch’s bacillus, is a spore-forming anaerobic bacterium that is known to cause food poisoning and gas gangrene [1]. In immunocompromised patients, C. perfringens infection has been reported to cause non-traumatic gas gangrene, severe hemolysis, and death within a short time period [2–4]. However, information on this infection in cases of hematologic malignancies [5], especially multiple myeloma (MM), is extremely limited. Here, we report a MM patient complicated with acute severe intravascular hemolysis due to C. perfringens septicemia, who died within 4 h after symptom onset during salvage chemotherapy after targeted therapy, including immunomodulatory drugs and anti-CD38 monoclonal antibody therapeutics.
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影响因子：
13.2
作者：
Kiu R;Hall LJ
通讯作者：
Hall LJ
影响因子：
2.1
作者：
Liu F;Xue S;Zhang Y;Yang J;Hu J;Li D;Ma X;Wang J
通讯作者：
Wang J
大量血管内溶血是产气荚膜梭菌菌血症的重要因素
影响因子：
4.6
作者：
A. Suzaki;Shihoko Komine;H. Nishiyama;S. Hayakawa
通讯作者：
S. Hayakawa
DOI：
--
发表时间：
2010-09
期刊：
The Netherlands journal of medicine
影响因子：
--
作者：
C. C. Bunderen-C.;M. Bomers;E. Wesdorp;PaulG. H. Peerbooms;J. Veenstra
通讯作者：
C. C. Bunderen-C.;M. Bomers;E. Wesdorp;PaulG. H. Peerbooms;J. Veenstra
影响因子：
1.5
作者：
Fukui S;Kogawa R;Hojo A;Kawamura W;Kura Y;Monma C;Uehara Y;Sawada U
通讯作者：
Sawada U