HIGH EXPRESSION RATE OF TN ANTIGEN IN METASTATIC LESIONS OF UTERINE CERVICAL CANCERS
HIGH EXPRESSION RATE OF TN ANTIGEN IN METASTATIC LESIONS OF UTERINE CERVICAL CANCERS
复制标题
DOI：
10.1016/0304-3835(93)90239-6
复制
发表时间：
1993-11-01
期刊：
影响因子：
9.7
通讯作者：
AONO, T
中科院分区：
文献类型：
--
作者：
HAMADA, S;FURUMOTO, H;AONO, T
通过对29例宫颈癌原发灶和转移灶中T抗原和Tn抗原表达的研究，探讨MN血型抗原表达改变的意义。用花生凝集素（PNA）凝集素作T抗原，野豌豆凝集素（VVA）凝集素作Tn抗原，用ABC法测定了这些抗原。29例转移灶中10例表达Tn抗原的癌细胞比例高于原发灶，1例低于原发灶，原发灶与转移灶相似者18例。29例转移灶中24例（82.8%）Tn抗原阳性，29例原发灶中17例（58.5%）Tn抗原阳性。转移灶Tn抗原表达率明显高于原发灶（P < 0.05）。转移瘤与原发瘤T抗原表达无明显差异。这些结果支持了我们先前的观点，即Tn抗原的表达与区域淋巴结转移密切相关，并可能反映了这种碳水化合物在宫颈癌转移过程中的重要作用。
The significance of altered expression of MN blood group antigens was examined by studies on the expressions of Thomsen-Friedenreich antigen (T antigen) and Tn antigen in primary and metastatic lesions of 29 human uterine cervical cancers. These antigens were measured by the avidin-biotin-peroxidase (ABC) method with peanut agglutinin (PNA) lectin for T antigen and Vicia villosa agglutinin (VVA) lectin for Tn antigen' Proportion of cancer cells expressing Tn antigen was higher in the metastatic lesions than in the primary tumors in 10 of the 29 cases, less in the metastasis than in the primary tumor in one case, and similar in the primary and metastatic lesions in the other, 18 cases. Reaction for Tn antigen was positive in 24 (82.8%) of the 29 metastases, and in 17 (58.5%) of the 29 primary lesions. Thus, the rate of Tn antigen expression was significantly higher in the metastases than in the primary lesions (P < 0.05). On the other hand, there was no significant difference between the immunoreactivities of T antigen in metastases and primary tumors. These findings support our previous suggestion that expression of Tn antigen is closely related to the metastasis to regional lymph nodes and may reflect an important role of this carbohydrate in the process of metastasis of cervical cancer.