Precise delivery of a multifunctional nanosystem for MRI-guided cancer therapy and monitoring of tumor response by functional diffusion-weighted MRI
Precise delivery of a multifunctional nanosystem for MRI-guided cancer therapy and monitoring of tumor response by functional diffusion-weighted MRI
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精确交付用于 MRI 引导癌症治疗的多功能纳米系统，并通过功能扩散加权 MRI 监测肿瘤反应
DOI：
10.1039/c8tb03153c
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发表时间：
2019-05-14
影响因子：
7
通讯作者：
Luo, Liangping
中科院分区：
文献类型：
--
作者：
Xiao, Zeyu;Chan, Leung;Luo, Liangping
合理设计影像引导的高效肿瘤靶向递送系统对于提高癌症治疗效果具有深远的意义。在此，合成了cRGD肽功能化聚乳酸-乙醇酸(cRGD-PLGA)嵌段共聚物，以封装阿霉素(DOX)和超顺磁性氧化铁(SPIO)，用于磁共振成像(MRI)引导的癌症治疗。该胶束在生理条件下表现出优异的 pH 响应药物释放特性和整合素靶向能力。在一项体内研究中，与 DOX 药物治疗相比，cRGD-PLGA-SPIO@DOX 胶束表现出更好的抗肿瘤作用并降低了毒性。胶束可以充当实时治疗监测的治疗诊断剂。重要的是，弥散加权 MRI 用于预测和监测纳米医学治疗中的癌症治疗反应。此外，与 DOX 相比，胶束还表现出更好的药效学特征，并且副作用显着减少。总之，我们进行了一项概念验证研究，证明 cRGD-PLGA-SPIO@DOX 胶束是一种用于 MR 成像引导的癌症治疗诊断的高效纳米颗粒药物递送平台。总而言之，这项研究提供了一种将功能性扩散加权 MRI 技术与功能化纳米胶束相结合的新策略，以实现精确的癌症治疗诊断。
The rational design of imaging-guided, highly efficient tumor-targeted delivery systems is of profound importance for improving cancer therapeutic efficacy. Herein, a cRGD peptide-functionalized poly(lactic-co-glycolic acid) (cRGD-PLGA) block copolymer was synthesized to encapsulate doxorubicin (DOX) and superparamagnetic iron oxide (SPIO) for magnetic resonance imaging (MRI)-guided cancer therapy. The micelles exhibited excellent pH-responsive drug release properties under physiological conditions and integrin-targeting ability. In an in vivo study, cRGD-PLGA-SPIO@DOX micelles exhibited improved antitumor effects and reduced toxicity compared with DOX drug treatment. The micelles can act as a theranostic agent for real-time therapeutic monitoring. Importantly, diffusion-weighted MRI was utilized to predict and monitor the cancer treatment response in nanomedicine therapy. Furthermore, the micelles also exhibited a preferable pharmacodynamic profile and significantly reduced side effects compared with DOX. In summary, we performed a proof-of-concept study demonstrating that cRGD-PLGA-SPIO@DOX micelles are a high-efficiency nanoparticulate drug-delivery platform for MR imaging-guided cancer theranostics. Taken together, this study provides a new strategy for combining functional diffusion-weighted MRI techniques and functionalized nanomicelles for precise cancer theranostics.