OCCUPATION AND RISK FOR TESTICULAR CANCER - A CASE-CONTROL STUDY
OCCUPATION AND RISK FOR TESTICULAR CANCER - A CASE-CONTROL STUDY
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DOI：
10.1093/ije/19.4.825
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发表时间：
1990-12-01
影响因子：
7.7
通讯作者：
JAVADPOUR, N
中科院分区：
文献类型：
--
作者：
HAYES, RB;BROWN, LM;JAVADPOUR, N
对 271 例 18-42 岁睾丸癌病例（包括 60 例精原细胞瘤和 206 例其他生殖细胞肿瘤）和 259 例对照进行了病例对照研究，以研究职业与睾丸癌风险之间的关联。 研究对象是在三个医疗中心确定的，其中两个医疗中心治疗军事人员。 对照组是被诊断患有生殖道以外癌症的男性。 专业就业（行政人员、教师和其他专业人员）与睾丸精原细胞瘤风险之间存在关联，OR = 2.8（95% Cl：1.4-5.4），生产工作就业与其他生殖细胞肿瘤风险之间存在关联，OR = 1.8（95% Cl：1.1-2.7）。 这些广泛群体中没有特定职业导致观察到的增长。 自我报告暴露于微波和其他无线电波与精原细胞瘤和其他生殖细胞肿瘤的过高风险相关。 然而，基于职称的无线电波暴露评估并不支持这一发现。 尽管近几十年来，年轻男性中睾丸癌的发病率一直在增加，但职业因素似乎并没有在研究人群中占睾丸癌发生的很大比例。
A case-control study of 271 testicular cancer cases aged 18-42, including 60 seminomas and 206 other germinal cell tumours, and 259 controls was carried out to study the association between occupation and testicular cancer risk. Study subjects were identified at three medical centres, two of which treat military personnel. Controls were men diagnosed with a cancer other than of the genital tract. Associations were identified between professional employment (administrators, teachers and other professionals) and risk for testicular seminoma, OR = 2.8 (95% Cl: 1.4-5.4) and between employment in production work and risk for other germinal cell tumours, OR = 1.8 (95% Cl: 1.1-2.7). No specific occupations within these broad groups were responsible for the observed increases. Self-reported exposure to microwaves and other radio waves was associated with an excess risk for both seminomas and other germinal cell tumours. However, an assessment of radio wave exposure based on job title did not support this finding. Although testicular cancer has been increasing in recent decades among young males, occupational factors did not appear to account for a substantial proportion of testicular cancer occurrence in the population studied.