Theoretical analysis of the thermal effects during in vivo tissue electroporation
Theoretical analysis of the thermal effects during in vivo tissue electroporation
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DOI：
10.1016/j.bioelechem.2003.07.001
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发表时间：
2003-10-01
影响因子：
5
通讯作者：
Lir, LM
中科院分区：
文献类型：
--
作者：
Davalos, RV;Rubinsky, B;Lir, LM
组织电穿孔是一种通过向身体的特定区域施加一系列短电脉冲来促进分子引入细胞的技术。这些脉冲暂时增加细胞膜对小药物和大分子的渗透性。本文的目的是提供有关这些电脉冲热效应的信息，以供设计电穿孔方案时考虑。研究的参数包括电极几何形状、血流量、代谢热产生、脉冲频率和通过电极的散热。创建基本的有限元模型是为了获得洞察力并权衡每个参数的重要性。结果表明，对于板电极，脉冲能量可用于充分估计组织中的加热。然而，对于针电极来说，在确定组织中的热分布时，几何形状（即间距和直径）以及脉冲频率至关重要。 (C) 2003 Elsevier B.V. 保留所有权利。
Tissue electroporation is a technique that facilitates the introduction of molecules into cells by applying a series of short electric pulses to specific areas of the body. These pulses temporarily increase the permeability of the cell membrane to small drugs and macromolecules. The goal of this paper is to provide information on the thermal effects of these electric pulses for consideration when designing electroporation protocols. The parameters investigated include electrode geometry, blood flow, metabolic heat generation, pulse frequency, and heat dissipation through the electrodes. Basic finite-element models were created in order to gain insight and weigh the importance of each parameter. The results suggest that for plate electrodes, the energy from the pulse may be used to adequately estimate the heating in the tissue. However, for needle electrodes, the geometry, i.e. spacing and diameter, and pulse frequency are critical when determining the thermal distribution in the tissue. (C) 2003 Elsevier B.V. All rights reserved.