RANK is essential for osteoclast and lymph node development
RANK is essential for osteoclast and lymph node development
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DOI：
10.1101/gad.13.18.2412
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发表时间：
1999-09-15
影响因子：
10.5
通讯作者：
Schuh, J
中科院分区：
文献类型：
--
作者：
Dougall, WC;Glaccum, M;Schuh, J
通过生成 RANK 缺陷小鼠来研究 TNF 受体 (TNFR) 家族成员 RANK 的生理作用。 RANK(-/-)小鼠的特征是由于破骨细胞分化明显受阻而导致的严重骨石症。巨噬细胞和树突状细胞从其骨髓前体细胞的定型、分化和功能成熟不需要RANK表达，但它为骨髓源性破骨细胞的分化提供了必要且特异的信号。 RANK(-/-)小鼠的脾脏中也表现出明显的B细胞缺陷。 RANK(-/-)小鼠保留了包括派尔氏淋巴结在内的粘膜相关淋巴组织，但完全缺乏所有其他外周淋巴结，这凸显了RANK在淋巴结形成中的另一个主要作用。这些实验表明，RANK 提供了淋巴结器官发生和破骨细胞分化所需的关键信号。
The physiological role of the TNF receptor (TNFR) family member, RANK, was investigated by generating RANK-deficient mice. RANK(-/-) mice were characterized by profound osteopetrosis resulting from an apparent block in osteoclast differentiation. RANK expression was not required for the commitment, differentiation, and functional maturation of macrophages and dendritic cells from their myeloid precursors but provided a necessary and specific signal for the differentiation of myeloid-derived osteoclasts. RANK(-/-) mice also exhibited a marked deficiency of B cells in the spleen. RANK(-/-) mice retained mucosal-associated lymphoid tissues including Peyer's patches but completely lacked all other peripheral lymph nodes, highlighting an additional major role for RANK in lymph node formation. These experiments reveal that RANK provides critical signals necessary for lymph node organogenesis and osteoclast differentiation.