Prognostic implications of human leukocyte antigen class I expression in patients who underwent surgical resection for non-small-cell lung cancer
Prognostic implications of human leukocyte antigen class I expression in patients who underwent surgical resection for non-small-cell lung cancer
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DOI：
10.1016/j.jss.2012.07.029
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发表时间：
2013-05-15
影响因子：
2.2
通讯作者：
Tanaka, Fumihiro
中科院分区：
文献类型：
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作者：
Hanagiri, Takeshi;Shigematsu, Yoshiki;Tanaka, Fumihiro
背景：本研究旨在探讨非小细胞肺癌(NSCLC)患者手术切除后人类白细胞抗原(HLAI)类分子表达的预后意义。结果：正常表达组124个肿瘤、异质性表达组181个肿瘤和低表达组98个肿瘤组织中检测到HLAI类分子的表达。根据HLAI类表达，正常组、异质性组和减低组患者术后5年生存率分别为76.6%、65.9%和76.1%。正常表达组的预后明显好于异质性组。结论：与异质性表达组相比，HLAI类表达正常组患者预后较好，但表达正常组与低表达组之间差异无统计学意义。(C)2013 Elsevier Inc.保留所有权利。
Background: The purpose of the present study was to clarify the prognostic significance of human leukocyte antigen (HLA) class I expression in patients with non-small-cell lung cancer who underwent complete surgical resection.Patients and methods: The expression of HLA class I molecules was evaluated in 403 resected NSCLC specimens using immunohistochemistry. The results were scored as the percentage of stained tumor cells and were categorized into three groups: 0%-24% (decreased), 25%-79% (heterogeneous), and 80% or more (normal).Results: The expression of HLA class I was evaluated in 124 tumors in the normal expression group, 181 tumors in the heterogeneous expression group, and 98 tumors in the decreased expression group. The 5-year survival rate of all patients after surgery according to the HLA class I expression in the normal, heterogeneous, and decreased groups was 76.6%, 65.9%, and 76.1%, respectively. The prognosis was significantly better in the normal expression group than in the heterogeneous group. Normal HLA class I expression also correlated with favorable survival in patients with stage I disease.Conclusions: The normal expression of HLA class I was associated with a favorable prognosis compared with the heterogeneous expression group, but no significant difference was observed between the normal expression and decreased expression groups. (C) 2013 Elsevier Inc. All rights reserved.