Regional changes in glucose metabolism during brain development from the age of 6 years
Regional changes in glucose metabolism during brain development from the age of 6 years
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DOI：
10.1006/nimg.1998.0346
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发表时间：
1998-07-01
期刊：
影响因子：
5.7
通讯作者：
Goldman, S
中科院分区：
文献类型：
--
作者：
Van Bogaert, P;Wikler, D;Goldman, S
对42名6至38岁受试者的正电子发射断层扫描(PET)和[F-18]氟代脱氧葡萄糖(FDG)研究进行了统计参数图分析，以确定根据全球活动调整后的糖代谢区域分布的年龄相关变化。成年人是正常的志愿者，而儿童患有特发性癫痫。我们研究了年龄的多项式展开以识别非线性效应，发现调整后的葡萄糖代谢在丘脑和前扣带回皮质变化非常显著，在基底节、中脑、岛叶、后扣带回、额叶和中央后皮质变化较小。回归图显示最佳拟合不是线性的：调整后的糖代谢主要在25岁之前增加，然后保持相对稳定。当服用抗癫痫药物和摄取FDG期间的睡眠被认为是混杂的协变量时，这种影响仍然存在。为了确定所观察到的代谢变化是否不是由于儿童的癫痫状况，我们将成人颞叶癫痫患者的PET数据与我们组的正常成人对象的PET数据进行了比较，导致与年龄相关的区域缺乏标测。这项研究表明，大脑从6岁开始成熟会导致丘脑中突触活动的相对增加，这可能是皮质-丘脑连接改善的结果。前扣带回皮质代谢活动的增加可能与这些丘脑的变化有关，并表明边缘系统参与了大脑成熟的过程，(C)1998年学术出版社。
Positron emission tomography (PET) with [F-18]fluorodeoxyglucose (FDG) studies of 42 subjects ages 6 to 38 years were analyzed using statistical parametric mapping to identify age-related changes in regional distribution of glucose metabolism adjusted for global activity. Whereas adults were normal volunteers, children had idiopathic epilepsy. We studied polynomial expansions of age to identify nonlinear effects and found that adjusted glucose metabolism varied very significantly in the thalamus and the anterior cingulate cortex and to a lesser degree in the basal ganglia, the mesencephalon, and the insular, posterior cingulate, frontal, and postcentral cortices. Regression plots showed that the best fit was not linear: adjusted glucose metabolism increased mainly before the age of 25 years and then remained relatively stable. Effects persisted when anti-epileptic drug intake and sleep during the FDG uptake were considered as confounding covariates. To determine if the metabolic changes observed were not due to the epileptic condition of the children, PET data obtained in adults with temporal lobe epilepsy were compared with those in our group of normal adult subjects, resulting in the absence of mapping in the age-related regions. This study suggests that brain maturation from the age of 6 years gives rise to a relative increase of synaptic activities in the thalamus, possibly as a consequence of improved corticothalamic connections. Increased metabolic activity in the anterior cingulate cortex is probably related to these thalamic changes and suggests that the limbic system is involved in the processes of brain maturation, (C) 1998 Academic Press.