Effect of long-term exercise on regional myocardial function and coronary collateral development after gradual coronary artery occlusion in pigs.
Effect of long-term exercise on regional myocardial function and coronary collateral development after gradual coronary artery occlusion in pigs.
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DOI：
10.1161/01.cir.82.5.1778
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发表时间：
1990-11
期刊：
影响因子：
37.8
通讯作者：
D. Roth;F. White;M. Nichols;S. L. Dobbs;J. Longhurst;C. Bloor
中科院分区：
文献类型：
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作者：
D. Roth;F. White;M. Nichols;S. L. Dobbs;J. Longhurst;C. Bloor
用Ameroid封堵器逐渐封堵猪冠状动脉左回旋支（LCx），观察长期运动诱发的心肌缺血对局部心肌功能和冠状动脉侧支形成的影响。术后30天，在运动过程中对22只猪的局部心肌功能和血流进行了评估，这些猪分为运动组（n = 12）和安静组（n = 10）。运动组在跑步机上训练25 ± 1天，30-50 min/d，心率210-220次/min。5周后，再次进行运动试验。在运动组中，训练后，我们观察到收缩期室壁增厚的改善，以休息百分比表示，在侧支依赖性LCx区域，从64 +/- 8%至87 +/- 6%（p小于0.01），在中度运动水平（220次/分）和45 +/- 7%至73 +/- 7%（p小于0.01），在重度运动水平（265次/分）。在5周后的剧烈运动期间，LCx区域的心室壁心肌血流量（表示为左心室非闭塞区域的流量比率）也显著增加（p <0.01）。与初始运动试验相比，久坐组在中等运动期间LCx区域的收缩期壁增厚有所改善（p <0.05），但在5周后的剧烈运动期间收缩期壁增厚或心肌血流比率无显著变化。我们的结论是，在猪逐渐LCx冠状动脉闭塞后，长期运动可改善运动过程中侧支依赖性心肌的心肌功能和冠状动脉侧支储备。
The effect of myocardial ischemia, induced by long-term exercise, on regional myocardial function and coronary collateral development was examined in pigs after gradual occlusion of the left circumflex coronary artery (LCx) with an ameroid occluder. Thirty days after surgery, regional myocardial function and blood flow were assessed during exercise in 22 pigs separated into exercise (n = 12) and sedentary groups (n = 10). The exercise group trained on a treadmill for 25 +/- 1 days, 30-50 min/day, at heart rates of 210-220 beats/min. After 5 weeks, another exercise test was performed. In the exercise group, after training, we observed an improvement in systolic wall thickening, expressed as a percentage of rest, in the collateral-dependent LCx region from 64 +/- 8% to 87 +/- 6% (p less than 0.01) at moderate exercise levels (220 beats/min) and from 45 +/- 7% to 73 +/- 7% (p less than 0.01) at severe exercise levels (265 beats/min). Transmural myocardial blood flow in the LCx region expressed as a ratio of flow in the nonoccluded region of the left ventricle also increased significantly (p less than 0.01) during severe exercise after 5 weeks. The sedentary group showed an improvement in systolic wall thickening in the LCx region during moderate exercise compared with the initial exercise test (p less than 0.05) but no significant change in systolic wall thickening or myocardial blood flow ratios during severe exercise after 5 weeks. We conclude that long-term exercise after gradual LCx coronary artery occlusion in pigs improves myocardial function and coronary collateral reserve in collateral-dependent myocardium during exercise.