Long-term tryptophan administration enhances cognitive performance and increases 5HT metabolism in the hippocampus of female rats
Long-term tryptophan administration enhances cognitive performance and increases 5HT metabolism in the hippocampus of female rats
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DOI：
10.1007/s00726-005-0310-x
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发表时间：
2006-11-01
期刊：
影响因子：
3.5
通讯作者：
Haleem, D. J.
中科院分区：
文献类型：
--
作者：
Haider, S.;Khaliq, S.;Haleem, D. J.
各种研究表明，5-羟色胺能神经传递的增加与记忆巩固的增加有关，而脑内5-羟色胺含量低则会损害记忆能力。在研究的第一阶段，我们发现给予色氨酸(Trp，Trp)6周后，血浆Trp和全脑Trp、5HT和5HIAA水平升高。学习过程涉及许多脑区，尤其是海马区，在学习和记忆中起着关键作用。因此，本研究旨在探讨色氨酸负荷对大鼠海马5HT代谢和认知能力的影响。Trp组大鼠在放射臂迷宫实验(RAM)中发现隐藏的食物奖赏的时间显著减少，表现出空间增强。本研究的重要发现是，在用色氨酸处理的大鼠中，海马区5-羟色胺代谢的增加比其他任何脑区的增加都要大。海马区5-羟色胺代谢的增加强调了该区域参与记忆过程。
It has been shown in various studies that increase in serotonergic neurotransmission is associated with increased memory consolidation whereas low brain 5HT impairs memory performance. In the first phase of our study we found that tryptophan (TRP) administration for 6 weeks increased plasma TRP and whole brain TRP, 5HT and 5HIAA levels. Many brain regions are involved in the learning process but particularly the hippocampus is known to have key role in learning and memory.The present study was therefore designed to investigate the effects of TRP loading particularly on hippocampal 5HT metabolism and cognitive performance in rats. TRP-treated rats demonstrated spatial enhancement as evidenced by a significant decrease in time to find the hidden food reward in radial arm maze test (RAM). The important finding of the present study was the greater increase in the 5HT metabolism in hippocampus than in any other brain region of the TRP-treated rats. This increased 5HT metabolism in the hippocampus emphasizes the involvement of this region in memory process.