Tumor-promoting macrophages induce the expression of the macrophage-specific receptor CD163 in malignant cells
Tumor-promoting macrophages induce the expression of the macrophage-specific receptor CD163 in malignant cells
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DOI：
10.1002/ijc.27506
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发表时间：
2012-11-15
影响因子：
6.4
通讯作者：
Moller, Holger Jon
中科院分区：
文献类型：
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作者：
Maniecki, Maciej Bogdan;Etzerodt, Anders;Moller, Holger Jon
肿瘤相关巨噬细胞(TAMs)是一种独特的促癌表型，被认为在肿瘤的形成和转移中起关键作用。本研究旨在探讨单核/巨噬细胞限制性受体CD163在膀胱癌组织中的表达，并探讨其诱导肿瘤细胞表达CD163的可能机制。CD163mRNA高表达(n=87)与较差的13年总生存期显著相关(对数等级检验，？2=8.931；p=0.0028)。此外，CD163mRNA在肌肉浸润性癌(T2T4)和侵袭性癌(III/IV级)中的表达显著增加(p=0.017，p=0.015)。IL-6的表达与局部IL-6的表达密切相关(r=0.72；p
Tumor-associated macrophages (TAMs) represent a distinct malignancy-promoting phenotype suggested to play a key role in tumor formation and metastasis. We aimed to investigate the expression of the monocyte/macrophage-restricted receptor CD163 in bladder tumor biopsies and assess the potential mechanism inducing the CD163 expression in tumor cells. A high CD163 mRNA expression (n = 87) was significantly associated with a poor 13-year overall survival (log-rank test, ?2 = 8.931; p = 0.0028). Moreover, CD163 mRNA expression was significantly increased in muscle invasive (T2T4), p = 0.017, and aggressive (grade III/IV) cancers (p = 0.015). The expression strongly correlated with local expression of IL-6 (r = 0.72; p