Long range projections of oxytocin neurons in the marmoset brain.
Long range projections of oxytocin neurons in the marmoset brain.
复制标题
狨猴大脑中催产素神经元的长距离投射。
DOI：
10.1101/2024.01.02.573953
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Miller,CoryT
中科院分区：
文献类型：
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作者：
Lefevre,Arthur;Meza,Jazlynn;Miller,CoryT
神经激素催产素（OT）已成为开发新的治疗策略，以治疗精神疾病，如自闭症谱系障碍的主要目标，因为它在管理哺乳动物社会行为的许多方面的不可或缺的作用。虽然在啮齿动物中的广泛工作已经产生了我们对OT的大部分知识，但我们缺乏有关灵长类动物神经生物学的基本信息，因此难以解释OT操作对人类患者的有限影响。事实上，以前的研究只揭示了灵长类动物大脑中有限的OT纤维。在这里，我们研究了OT连接组在绒猴使用免疫组织化学，并映射OT纤维在整个大脑的成年男性和女性绒猴。我们发现OT投射广泛地到达边缘系统和参与社会行为调节的皮质区域，如杏仁核、内侧前额叶皮质和基底神经节。在绒猴中观察到的OT纤维模式与啮齿动物中描述的OT连接体非常相似。我们的研究结果与以前的结果相比，证明了OT在整个绒猴大脑中的广泛分布。鉴于这种神经激素在灵长类动物大脑中的普遍存在，在啮齿动物中开发的操纵内源性OT的方法可能适用于绒猴。
The neurohormone oxytocin (OT) has become a major target for the development of novel therapeutic strategies to treat psychiatric disorders such as autism spectrum disorder because of its integral role in governing many facets of mammalian social behavior. Whereas extensive work in rodents has produced much of our knowledge of OT, we lack basic information about its neurobiology in primates making it difficult to interpret the limited effects that OT manipulations have had in human patients. In fact, previous studies have revealed only limited OT fibers in primate brains. Here, we investigated the OT connectome in marmoset using immunohistochemistry, and mapped OT fibers throughout the brains of adult male and female marmoset monkeys. We found extensive OT projections reaching limbic and cortical areas that are involved in the regulation of social behaviors, such as the amygdala, the medial prefrontal cortex, and the basal ganglia. The pattern of OT fibers observed in marmosets is notably similar to the OT connectomes described in rodents. Our findings here contrast with previous results by demonstrating a broad distribution of OT throughout the marmoset brain. Given the prevalence of this neurohormone in the primate brain, methods developed in rodents to manipulate endogenous OT are likely to be applicable in marmosets.