The development of direction selectivity in ferret visual cortex requires early visual experience
The development of direction selectivity in ferret visual cortex requires early visual experience
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DOI：
10.1038/nn1684
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发表时间：
2006-05-01
影响因子：
25
通讯作者：
White, LE
中科院分区：
文献类型：
--
作者：
Li, Y;Fitzpatrick, D;White, LE
人们认为，定义感觉皮层中柱的选择性反应特性的发展在皮层成熟的早期就开始了，而不需要经验。我们利用光学成像和电生理学技术研究了雪貂视觉皮层方向选择性的发展，并发现了这一观点的例外。与方向选择性和眼优势不同，在睁眼时未检测到方向选择性。几天后，方向选择性出现，并在接下来的两周内增强到成人水平。视觉体验对于这个过程至关重要，暗饲养雪貂缺乏方向选择性就表明了这一点。尽管反应幅度、刺激方向的偏好和带宽、空间和时间频率以及对比度都恢复了，但在这段时期之后给予经验的暗饲养雪貂中，这种损伤仍然存在。出生后早期的视觉体验在皮质方向选择性的发展中发挥着必要且独特的作用。
Development of the selective response properties that define columns in sensory cortex is thought to begin early in cortical maturation, without the need for experience. We investigated the development of direction selectivity in ferret visual cortex using optical imaging and electrophysiological techniques and found an exception to this view. Unlike orientation selectivity and ocular dominance, direction selectivity was not detected at eye opening. Direction selectivity emerged several days later and strengthened to adult levels over the following 2 weeks. Visual experience was essential for this process, as shown by the absence of direction selectivity in dark-reared ferrets. The impairment persisted in dark-reared ferrets that were given experience after this period, despite the recovery of response amplitude, preference and bandwidth for stimulus orientation, spatial and temporal frequency, and contrast. Visual experience in early postnatal life plays a necessary and unique role in the development of cortical direction selectivity.