Biomimetic Reactivity of Oxygen-Derived Manganese and Iron Porphyrinoid Complexes.
Biomimetic Reactivity of Oxygen-Derived Manganese and Iron Porphyrinoid Complexes.
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DOI：
10.1021/acs.chemrev.7b00180
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发表时间：
2017-11-08
期刊：
影响因子：
62.1
通讯作者：
Goldberg DP
中科院分区：
文献类型：
--
作者：
Baglia RA;Zaragoza JPT;Goldberg DP
血红素蛋白利用血红素辅因子，铁卟啉，进行各种各样的反应，包括分子氧结合和运输，电子转移和氧化/氧化。这些反应共有几种关键的金属卟啉中间体，通常衍生自分子氧及其同系物如过氧化氢，并且由金属-分子氧、金属-超氧、金属-过氧和金属-氧加合物组成。已经合成了各种各样的合成金属卟啉配合物，以产生和稳定这些中间体，然后用于确定这些物种在受控和明确定义的环境中的光谱特征，结构和反应性。在这篇综述中，我们总结了最近的研究结果，这些物种与常见的卟啉类支架仿生研究。强调了拟议的行动机制。综述按金属氧中间体的结构类型进行组织，并根据金属（锰，铁）和卟啉类配体（卟啉，可咯，可咯嗪）分为几个部分。
Heme proteins utilize the heme cofactor, an iron porphyrin, to perform a diverse range of reactions including dioxygen binding and transport, electron transfer, and oxidation/oxygenations. These reactions share several, key metalloporphyrin intermediates, typically derived from dioxygen and its congeners such as hydrogen peroxide, and which are comprised of metal-dioxygen, metal-superoxo, metal-peroxo, and metal-oxo adducts. A wide variety of synthetic metalloporphyrinoid complexes have been synthesized to generate and stabilize these intermediates, and then employed to determine the spectroscopic features, structures, and reactivities of such species in controlled and well-defined environments. In this review, we summarize recent findings on the reactivity of these species with common porphyrinoid scaffolds employed for biomimetic studies. The proposed mechanisms of action are emphasized. The review is organized by structural type of metal-oxygen intermediate, and broken into subsections based on the metal (manganese, iron) and porphyrinoid ligand (porphyrin, corrole, corrolazine).
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