Establishing Central Sensitization-Related Symptom Severity Subgroups: A Multicountry Study Using the Central Sensitization Inventory
Establishing Central Sensitization-Related Symptom Severity Subgroups: A Multicountry Study Using the Central Sensitization Inventory
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建立中枢致敏相关症状严重程度亚组：使用中枢致敏清单的多国研究
DOI：
10.1111/papr.13005
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发表时间：
2020
期刊：
影响因子：
3.1
通讯作者：
Luciano JV.
中科院分区：
文献类型：
--
作者：
Cuesta-Vargas AI;Neblett R;Nijs J;Chiarotto A;Kregel J;van Wilgen CP;Pitance L;Knezevic A;Gatchel RJ;Mayer TG;Viti C;Roldan-Jimnez C;Testa M;Caumo W;Jeremic-Knezevic M;Nishigami T;Feliu-Soler A; Luciano JV.
目的越来越多的证据表明疼痛部位会影响中枢敏感化(CS)相关症状。此外，疼痛部位和疼痛持续时间可能与CS相关症状有错综复杂的关系。然而，这些因素已经单独进行了调查。本研究旨在探讨肌肉骨骼疾病患者CS相关症状与疼痛部位和/或疼痛持续时间的关系。所有参与者都接受了疼痛部位、疼痛持续时间、中枢敏化问卷(CSI)、EuroQol-5维度和简明疼痛问卷的评估。根据疼痛部位(脊椎、四肢、脊柱和四肢疼痛)将受试者分为3组，根据疼痛持续时间(急慢性疼痛)将参与者分为2组。结果疼痛部位和疼痛持续时间在CSI评分上的交互作用不显著(P>；0.05)。脊柱和四肢疼痛患者与脊柱或四肢疼痛患者相比，CSI值较高的优势比(≥：40)为2.64(P<；P<0.0 1)，慢性疼痛患者与急性疼痛患者的优势比为1.3 1(P=0.5 2)。此外，慢性疼痛和“脊柱和四肢”疼痛合并时CSI评分较高的比例较高(23.1%，调整后残差系数=44.48)。结论疼痛部位独立影响CSI评分，脊柱和四肢疼痛与慢性疼痛相结合提示CSI评分较高。疼痛部位和疼痛持续时间的组合是指出CS相关症状的重要线索。
ObjectivesIncreased evidence indicates that pain location affects central sensitization (CS)‐related symptoms. In addition, pain location and pain duration may be intricately related to CS‐related symptoms. However, these factors have been investigated separately. This study aimed to investigate the association between CS‐related symptoms and pain location and/or pain duration in patients with musculoskeletal disorders.MethodsSix hundred thirty‐five participants with musculoskeletal disorders were included in this cross‐sectional study. All participants were assessed for pain location, pain duration, central sensitization inventory (CSI), EuroQol‐5 dimension, and brief pain inventory. The participants were categorized into 3 groups based on pain location (spinal, limb, and both spinal and limb pain) and into 2 groups based on pain duration (acute and chronic pain).ResultsThe interaction between pain location and pain duration were not significant on CSI score (P> 0.05). The odds ratio for higher CSI score (≥ 40) in patients with both spinal and limb pain vs. those with spinal or limb pain was 2.64 (P< 0.01) and that in patients with chronic pain vs. those with acute pain was 1.31 (P= 0.52). In addition, the prevalence of higher CSI scores in the combination of chronic and “both spinal and limb” pain was high (23.1%, adjusted residual = 4.48).ConclusionsPain location independently influenced CSI scores, and the combination of both spinal and limb pain and chronic pain indicated high CSI scores. The combination of pain location and pain duration is an important clue that points to CS‐related symptoms.