Association between improvements in insulin resistance and changes in cognitive function in elderly diabetic patients with normal cognitive function
Association between improvements in insulin resistance and changes in cognitive function in elderly diabetic patients with normal cognitive function
复制标题
DOI：
10.1111/j.1447-0594.2011.00691.x
复制
发表时间：
2011-07-01
影响因子：
3.3
通讯作者：
Sato, Yuzo
中科院分区：
文献类型：
--
作者：
Yanagawa, Madoka;Umegaki, Hiroyuki;Sato, Yuzo
目的：在发达国家，患有认知功能障碍的老年人数量不断增加。多项研究表明，糖尿病是认知功能下降的危险因素，最近，大量研究表明，运动可以改善胰岛素抵抗 (IR)。然而，尚未开展研究来检验 IR 与认知功能障碍之间的关系。方法：16 名老年糖尿病患者参与了这项研究（平均年龄 70.9 +/- 3.7 岁）。他们被分为对照组和训练组，指导训练组使用骑马模拟设备（JOBA）每周锻炼 4 天，持续 12 周。通过正常血糖钳夹技术测量胰岛素敏感性，并进行一些评估认知功能的测试，例如简易精神状态检查（MMSE）。结果：对照组和训练组之间的基线数据没有统计学上的显着差异。基线和随访之间的葡萄糖输注率值和延迟单词表评分的差异显着相关（P = 0.024）。此外，空腹血糖（FBS）和Trail Making Test B（TMT-B）评分的变化也具有相关性（P = 0.035）。结论：当前研究表明，为期12周的运动干预计划并没有显着改善老年糖尿病患者的IR。然而，IR 的变化与记忆功能的改善相关，而 FBS 的减少与 TMT-B 的改善相关。老年老年国际 2011； 11：341-347。
Aim: The number of elderly with cognitive dysfunction has been increasing in developed countries. Several studies have shown that diabetes is a risk factor for declines in cognitive function and, recently, numerous studies have demonstrated that exercise improves insulin resistance (IR). However, no studies have been undertaken to examine the relationship between IR and cognitive dysfunction.Methods: Sixteen elderly diabetic patients participated in this study (mean age 70.9 +/- 3.7 years). They were divided into control and training groups, and the training group was instructed to exercise 4 days per week for 12 weeks using horse riding simulation equipment (JOBA). Insulin sensitivity was measured by the euglycemic clamp technique and several tests to assess cognitive function, such as the Mini-Mental State Examination (MMSE), were performed.Results: There were no statistically significant differences between the control and training groups in the baseline data. The differences of glucose infusion rate values and delayed word list scores, between baseline and the follow up, were significantly correlated (P = 0.024). In addition, changes in fasting blood sugar (FBS) and in the Trail Making Test B (TMT-B) score were also correlated (P = 0.035).Conclusion: The current study showed that a 12-week exercise intervention program did not significantly improve IR in elderly diabetic patients. However, changes in IR were associated with improvements in memory function, and reduced FBS was associated with improvements in TMT-B. Geriatr Gerontol Int 2011; 11: 341-347.