Magnetic resonance imaging of the brain and cerebral proton spectroscopy in patients with systemic lupus erythematosus
Magnetic resonance imaging of the brain and cerebral proton spectroscopy in patients with systemic lupus erythematosus
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DOI：
10.1002/art.1780400107
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发表时间：
1997-01-01
影响因子：
--
通讯作者：
Harrison, MJG
中科院分区：
文献类型：
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作者：
Chinn, RJS;Wilkinson, ID;Harrison, MJG
Objective.通过磁共振成像（MRI）和磁共振波谱（MRS）研究系统性红斑狼疮（SLE）患者脑部病变的发生率和程度。SLE患者（47例女性）和对照组（25例女性）接受了1.5T MRI，半自动分割技术计算脑脊液（CSF）和脑体积。额叶和顶枕部白色物质的质子MRS产生N-乙酰基（NA）、胆碱和肌酸的代谢物比率。与对照组相比，SLE患者MRI上脑萎缩的发生率更高（32%对0%），通过CSF与颅内体积比的增加证实，患者也有陈旧性梗死和脑梗死（8.5% vs 0%）和更多的小白色病变（23%对8%有>5个此类病变），MRS显示NA峰相对减少，虽然没有患者在急性病时进行研究，但先前的神经系统受累与异常发现相关。MRI和MRS有助于研究SLE的脑并发症，存在慢性改变，可能是缺血性的，其确切的原因，后果和预防是当前的挑战。
Objective. To investigate the prevalence and extent of cerebral changes in patients with systemic lupus erythematosus (SLE) by magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS).Methods. SLE patients (47 women) and controls (25 women) underwent 1.5T MRI, A semiautomated segmentation technique calculated cerebrospinal fluid (CSF) and brain volumes. Proton MRS of the frontal and parieto-occipital white matter yielded metabolite ratios of N-acetyl groups (NA), choline, and creatine.Results. Compared with the control group, the SLE patients more often had cerebral atrophy on MRI (32% versus 0%), confirmed by an increase in the CSF to intracranial volume ratio, The patients also had old infarcts and hemorrhages (8.5% versus 0%) and more small white matter lesions (23% versus 8% had >5 such lesions), MRS showed relative reduction of NA peaks, Although no patient was studied when acutely ill, prior neurologic involvement was related to abnormal findings.Conclusion. MRI and MRS are helpful in the investigation of cerebral complications of SLE, There are chronic changes which may be ischemic in nature, Their precise cause, consequences, and prevention are current challenges.