FEASIBILITY STUDY FOR POSITRON EMISSION MAMMOGRAPHY
FEASIBILITY STUDY FOR POSITRON EMISSION MAMMOGRAPHY
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DOI：
10.1118/1.597169
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发表时间：
1994-04-01
期刊：
影响因子：
3.8
通讯作者：
MAKO, F
中科院分区：
文献类型：
--
作者：
THOMPSON, CJ;MURTHY, K;MAKO, F
一个可行性研究，提出了一个小型，低成本，专用设备的正电子发射乳腺摄影。乳房上方和下方的两个检测器阵列将被放置在传统的乳房X线摄影单元中。这些探测器对正电子湮没辐射敏感，并连接到符合电路和多平面图像存储器。通过在每条响应线的交叉点处递增存储器位置，在真实的时间内获得正电子发射同位素的分布的图像。蒙特卡罗模拟的乳房体模与实际扫描的这种体模在传统的PET扫描仪进行了比较。仿真和实验数据被用来预测所提出的系统的性能。使用非常窄的锗酸铋BGO晶体的空间分辨率实验表明，大约2 mm的空间分辨率应该是可能的。该设备的效率约为传统大脑扫描仪的十倍。散射部分较大，但散射辐射具有非常平坦的分布。通过将该装置设计成适合现有的乳房X线摄影单元，可以在注射放射性药物之后拍摄常规乳房X线摄影，从而允许发射图像和常规乳房X线摄影图像的精确配准。
A feasibility study is presented for a small, low-cost, dedicated device for positron emission mammography. Two detector arrays above and below the breast would be placed in a conventional mammography unit. These detectors are sensitive to positron annihilation radiation, and are connected to a coincidence circuit and a multiplane image memory. Images of the distribution of positron-emitting isotope are obtained in real time by incrementing the memory location at the intersection of each line of response. Monte Carlo simulations of a breast phantom are compared with actual scans of this phantom in a conventional PET scanner. The simulations and experimental data are used to predict the performance of the proposed system. Spatial resolution experiments using very narrow bismuth germanate BGO crystals suggest that spatial resolutions of about 2 mm should be possible. The efficiency of the proposed device is about ten times that of a conventional brain scanner. The scatter fraction is greater, but the scattered radiation has a very flat distribution. By designing the device to fit in an existing mammography unit, conventional mammograms can be taken after the injection of the radio-pharmaceutical allowing exact registration of the emission and conventional mammographic images.