Effect of epicardial application of amiodarone-releasing hydrogel on heart rate in an animal model
Effect of epicardial application of amiodarone-releasing hydrogel on heart rate in an animal model
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DOI：
10.21037/cdt.2019.04.01
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发表时间：
2019-08-01
影响因子：
2.4
通讯作者：
Bockeria, Olga L.
中科院分区：
文献类型：
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作者：
Kanametov, Teymuraz N.;Shvartz, Vladimir A.;Bockeria, Olga L.
背景：本实验旨在研究胺碘酮水凝胶局部应用的安全性，以及不同剂量对杂种兔心率的影响。方法：对46只家兔进行胺碘酮水凝胶材料心外膜局部应用。将兔子分为5组：第1组-水凝胶中胺碘酮的剂量1mg，第2组-剂量3mg；第3组-剂量6毫克；第4组-不含胺碘酮的水凝胶；组号5-胺碘酮静脉注射，60mg。结果：应用胺碘酮水凝胶不伴有全身炎症反应。第 2 组的心率显着降低（手术前：158 +/- 16，手术后：130 +/- 11，（P
Background: The purpose of the experiment was to study the safety of local epicardial use of the hydrogel with amiodarone, as well as the influence of its different dosages on the heart rate of mongrel rabbits.Methods: The epicardial application of the hydrogel material with amiodarone was performed in 46 rabbits. Rabbits were divided into 5 groups: Group No. 1-dose of amiodarone in the hydrogel 1 mg, Group No. 2-dose 3 mg; Group No. 3-dose 6 mg; Group No. 4-hydrogel without amiodarone; Group No. 5-amiodarone intravenously, 60 mg.Results: The application of hydrogel with amiodarone is not accompanied by a systemic inflammatory reaction. In group No. 2, there was a significant reduction in the heart rate (before surgery: 158 +/- 16, after: 130 +/- 11, (P