Exploring the genetics of aging in a wild passerine bird
Exploring the genetics of aging in a wild passerine bird
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DOI：
10.1086/521241
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发表时间：
2007-10-01
影响因子：
2.9
通讯作者：
Gustafsson, Lars
中科院分区：
文献类型：
--
作者：
Brommer, Jon E.;Wilson, Alastair J.;Gustafsson, Lars
衰老是随着生物体年龄的增长，生存和繁殖能力的下降，已知发生在白颈果蝇中。我们认为年度健身（估计的遗传贡献，一个人使明年的基因库）作为衡量特定年龄的健身。我们应用限制性最大似然线性混合模型的方法对25年的数据3,844名男性和4,992名女性领捕蝇草。年适合度具有显著的加性遗传成分（h（2）约为4%）。在以后的年龄，男女的年健身下降。使用随机回归动物模型，我们发现，所观察到的年龄相关的表型变化，每年健身不存在的加性遗传水平上，相反的预测衰老的遗传假设。我们的研究表明，野生动物的衰老模式需要从潜在的遗传学角度谨慎解释，因为它们可能在很大程度上由环境过程决定。
Senescence is the decline in survival and reproduction as an organism ages and is known to occur in collared flycatchers Ficedula albicollis. We consider annual fitness (the estimated genetic contribution that an individual makes to next year's gene pool) as a measure of age-specific fitness. We apply a restricted maximum likelihood linear mixed-model approach on 25 years of data on 3,844 male and 4,992 female collared flycatchers. Annual fitness had a significant additive genetic component (h(2) of about 4%). Annual fitness declined at later ages in both sexes. Using a random regression animal model, we show that the observed age-related phenotypic changes in annual fitness were not present on the additive genetic level, contrary to predictions of genetic hypotheses of senescence. Our study suggests that patterns of aging in the wild need to be interpreted with caution in terms of underlying genetics because they may be largely determined by environmental processes.