Endogenous lung stem cells: what is their potential for use in regenerative medicine?
Endogenous lung stem cells: what is their potential for use in regenerative medicine?
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DOI：
10.1586/ers.10.21
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发表时间：
2010-06-01
影响因子：
3.9
通讯作者：
McQualter, Jonathan L
中科院分区：
文献类型：
--
作者：
Bertoncello, Ivan;McQualter, Jonathan L
近年来，干细胞技术的进步引起了人们对利用成体和胚胎干细胞在再生医学中的潜力的极大兴趣。基于干细胞的治疗是治疗难治性肺病的一个特别有吸引力的选择，目前的治疗基本上是姑息性的。动物模型的原理验证实验表明，外源性干细胞通过减轻损伤后的纤维化反应来介导肺修复的功效，但也表明它们促进肺上皮再生和修复的能力有限。因此，人们的注意力转向内源性肺干细胞作为肺再生治疗的靶点或载体。在本文中，我们讨论了内源性肺干细胞在再生医学中的潜力和前景，以及研究人员和临床医生在利用其修复肺的潜力方面面临的问题和挑战。
Advances in stem cell technologies in recent years have generated considerable interest in harnessing the potential of adult and embryonic stem cells in regenerative medicine. Stem cell-based therapies are a particularly attractive option for the treatment of intractable lung diseases for which current therapies are essentially palliative. Proof-of-principle experiments in animal models demonstrate the efficacy of exogenous stem cells in mediating lung repair by attenuating fibrotic responses to injury, but also suggest that their ability to contribute to lung epithelial regeneration and repair is limited. Consequently, attention has turned to endogenous lung stem cells as targets or vehicles for the delivery of lung regenerative therapies. In this article, we discuss the potential and promise of endogenous lung stem cells in regenerative medicine, and the problems and challenges faced by researchers and clinicians in harnessing their potential to repair the lung.