Archaeal DNA repair: paradigms and puzzles
Archaeal DNA repair: paradigms and puzzles
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DOI：
10.1042/bst0310690
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发表时间：
2003-06-01
影响因子：
3.9
通讯作者：
White, MF
中科院分区：
文献类型：
--
作者：
White, MF
现在人们普遍认为，真核生物在信息处理途径上与真核生物有许多相似之处。古细菌和真核生物的DNA复制和转录机制表现出特别惊人的相似性，古细菌的过程已被广泛用作更复杂的真核生物过程的简单模型。细胞DNA修复途径尚未得到很好的表征，它们与细菌和真核生物中修复途径的关系仍然存在疑问。在古菌领域内，crenarchaea和euryarchaea之间也有很大的区别。这篇综述突出了一些这些相似性和差异，使用具体的例子所产生的双链和单链DNA结合蛋白和修复核酸内切酶XPF的crenarchaeote硫磺硫化叶菌的研究。
It is now generally accepted that the Archaea share many similarities in their information-processing pathways with eukarya. Archaeal and eukaryal DNA replication and transcriptional machineries show particularly striking similarities, and the archaeal processes have been used extensively as simpler models of the much more complex eukaryal ones. Archaeal DNA-repair pathways are not yet well characterized, and their relationship with repair pathways in bacteria and eukarya are still open to question. There are also strong distinctions between the major subdivisions crenarchaea and euryarchaea within the archaeal domain. This review highlights some of these similarities and differences using specific examples arising from our studies of the double-stranded and single-stranded DNA-binding proteins and the repair endonuclease XPF in the crenarchaeote Sulfolobus solfataricus.