A study of the dynamics of seizure propagation across micro domains in the vicinity of the seizure onset zone.
A study of the dynamics of seizure propagation across micro domains in the vicinity of the seizure onset zone.
复制标题
DOI：
10.1088/1741-2560/12/4/046016
复制
发表时间：
2015-08
影响因子：
4
通讯作者：
Anderson WS
中科院分区：
文献类型：
--
作者：
Basu I;Kudela P;Korzeniewska A;Franaszczuk PJ;Anderson WS
使用微电极阵列来测量大脑表面的电活动，作为一种改善癫痫发作区域定位的手段，越来越多地被研究。在这项工作中，我们使用多元自回归模型来确定由这种微电极阵列采样的70 - 110 Hz高频段内癫痫发作动力学的演变。我们使用了4例接受颅内监测的患者记录的7例复杂部分性癫痫，使用定向传递函数测量重建滑动窗口上癫痫发作的传播模式。我们证明了有向传递函数可以用来估计一组具有已知传播模式的模拟微电极数据中的癫痫发作活动流。一般来说，根据微电极网格相对于临床癫痫发作区域的位置和癫痫发作的时间，在2到10秒的时间尺度上，垂直传播的方向特征会发生变化，总的方向性被限制在大约9mm2的空间维度上。研究还发现，高频频带中最强的癫痫发作模式及其微域的来源随着时间的推移和在临床确定的癫痫发作区域边缘的癫痫发作比在内部的癫痫发作更稳定。这种类型的繁殖分析可能在未来为癫痫病医生提供一个额外的工具来表征癫痫组织。这将有助于在不损害基本脑功能的情况下缩小切除区域，并提供针对抗癫痫刺激装置的重要信息。
The use of micro-electrode arrays to measure electrical activity from the surface of the brain is increasingly being investigated as a means to improve seizure onset zone localization. In this work, we used a multivariate autoregressive model to determine the evolution of seizure dynamics in the 70 – 110 Hz high frequency band across micro-domains sampled by such micro-electrode arrays. We used 7 complex partial seizures recorded from 4 patients undergoing intracranial monitoring for surgical evaluation to reconstruct the seizure propagation pattern over sliding windows using a directed transfer function measure. We showed that a directed transfer function can be used to estimate the flow of seizure activity in a set of simulated micro-electrode data with known propagation pattern. In general, depending on the location of the micro-electrode grid with respect to the clinical seizure onset zone and the time from seizure onset, ictal propagation changed in directional characteristics over a 2 to 10 seconds time scale, with gross directionality limited to spatial dimensions of approximately 9mm2. It was also seen that the strongest seizure patterns in the high frequency band and their sources over such micro-domains are more stable over time and across seizures bordering the clinically determined seizure onset zone than inside. This type of propagation analysis might in future provide an additional tool to epileptologists for characterizing epileptogenic tissue. This will potentially help narrowing down resection zones without compromising essential brain functions as well as provide important information about targeting anti-epileptic stimulation devices.