Postnatal sex reversal of the ovaries in mice lacking estrogen receptors α and β
Postnatal sex reversal of the ovaries in mice lacking estrogen receptors α and β
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DOI：
10.1126/science.286.5448.2328
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发表时间：
1999-12-17
期刊：
影响因子：
56.9
通讯作者：
Korach, KS
中科院分区：
文献类型：
--
作者：
Couse, JF;Hewitt, SC;Korach, KS
培育缺乏雌激素受体α和β的小鼠是为了阐明每种受体在雌激素靶组织生理学中的作用。 αβ雌激素受体敲除（αβERKO）突变体的两性都表现出正常的生殖道发育，但不育。成年 αβ ERKO 雌性的卵巢表现出卵泡转分化为类似于睾丸曲细精管的结构，包括支持样细胞和苗勒氏管抑制物质、硫酸化糖蛋白-2 和 Sox9 的表达，因此，两种受体的丧失导致与个体 ERKO 突变体不同的卵巢表型，这表明 这两种受体都是维持产后卵巢中生殖细胞和体细胞所必需的。
Mice lacking estrogen receptors alpha and beta were generated to clarify the roles of each receptor in the physiology of estrogen target tissues. Both sexes of alpha beta estrogen receptor knockout (alpha beta ERKO) mutants exhibit normal reproductive tract development but are infertile. Ovaries of adult alpha beta ERKO females exhibit follicle transdifferentiation to structures resembling seminiferous tubules of the testis, including Sertoli-like cells and expression of Mullerian inhibiting substance, sulfated glycoprotein-2, and Sox9, Therefore, Loss of both receptors Leads to an ovarian phenotype that is distinct from that of the individual ERKO mutants, which indicates that both receptors are required for the maintenance of germ and somatic cells in the postnatal ovary.