The critical role of velocity storage in production of motion sickness
The critical role of velocity storage in production of motion sickness
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DOI：
10.1196/annals.1303.034
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发表时间：
2003-01-01
期刊：
影响因子：
--
通讯作者：
Raphan, T
中科院分区：
文献类型：
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作者：
Cohen, B;Dai, MJ;Raphan, T
我们建议，晕动病是通过前庭系统中的速度存储的取向特性来介导的，该取向特性倾向于将由角前庭眼反射（aVOR）产生的眼速度与重力惯性加速度（GIA）对齐。(GIA是作用在头部上的线性加速度的总和。在没有平移加速度的情况下，重力就是GIA。）我们进一步假设，由交叉耦合前庭刺激产生的晕动病的特征在于由眼旋转轴和GIA之间的差异，角运动的响应强度和响应持续时间组成的度量，由中央前庭时间常数，即速度存储的时间常数确定。前庭小脑的结节和悬雍垂可能是感觉到差异的中心部位，前庭时间常数习惯化的中心部位，以及与自主神经系统建立联系以产生症状和体征的中心部位。
We propose that motion sickness is mediated through the orientation properties of velocity storage in the vestibular system that tend to align eye velocity produced by the angular vestibulo-ocular reflex (aVOR) with gravitoinertial acceleration (GIA). (GIA is the sum of the linear accelerations acting on the head. In the absence of translational accelerations, gravity is the GIA.) We further postulate that motion sickness produced by cross-coupled vestibular stimulation can be characterized by a metric composed of the disparity between the axis of eye rotation and the GIA, the strength of the response to angular motion, and the response duration, as determined by the central vestibular time constant, that is, by the time constant of velocity storage. The nodulus and uvula of the vestibulocerebellum are likely to be the central sites where the disparity is sensed, where the vestibular time constants are habituated, and where links are made to the autonomic system to produce the symptoms and signs.