Neck Circumference as a Novel Measure of Cardiometabolic Risk: The Framingham Heart Study
Neck Circumference as a Novel Measure of Cardiometabolic Risk: The Framingham Heart Study
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DOI：
10.1210/jc.2009-1779
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发表时间：
2010-08-01
影响因子：
5.8
通讯作者：
Fox, Caroline S.
中科院分区：
文献类型：
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作者：
Preis, Sarah Rosner;Massaro, Joseph M.;Fox, Caroline S.
背景：颈围是上半身皮下脂肪的代表，可能是一个独特的脂肪库，除了中央身体脂肪之外，它还会带来额外的心血管风险。方法和结果：纳入了接受多排计算机断层扫描以评估内脏脂肪组织 (VAT) 的颈围测量参与者 [n = 3307，48% 为女性；n = 3307，其中 48% 为女性；平均年龄 = 51 岁；平均体重指数 (BMI) = 27.8 kg/m(2)；平均颈围 = 40.5 厘米（男性）和 34.2 厘米（女性）]。使用性别特异性线性回归模型来评估颈围SD增加与心血管疾病（CVD）危险因素（收缩压和舒张压；总胆固醇、低密度脂蛋白和高密度脂蛋白胆固醇和甘油三酯；以及空腹血糖、胰岛素、胰岛素原和胰岛素抵抗的稳态模型评估）之间的关联。颈围与增值税相关 [r = 0.63（男性）； r = 0.74（女性）； P < 0.001] 和 BMI [r = 0.79（男性）； r = 0.80（女性）； P<0.001]。进一步调整增值税后，颈围与男性的收缩压、舒张压、甘油三酯、女性的空腹血糖、胰岛素、胰岛素原和胰岛素抵抗的稳态模型评估呈正相关，与高密度脂蛋白呈负相关（所有 P 值 < 0.01）。在针对增值税和体重指数进行调整的模型中也观察到了类似的结果。在对 CVD 事件作为结果的二次分析中，在多变量调整模型中观察到颈围没有统计学上显着的关联。结论：即使在调整增值税和 BMI 后，颈围也与 CVD 危险因素相关。这些发现表明，上身皮下脂肪可能是一种独特的致病性脂肪库。 （临床内分泌代谢杂志 95：3701-3710，2010）
Background: Neck circumference, a proxy for upper-body sc fat, may be a unique fat depot that confers additional cardiovascular risk above and beyond central body fat.Methods and Results: Participants with neck circumference measures who underwent multidetector computed tomography to assess visceral adipose tissue (VAT) were included [n = 3307, 48% women; mean age = 51 yr; mean body mass index (BMI) = 27.8 kg/m(2); mean neck circumference = 40.5 cm (men) and 34.2 cm (women)]. Sex-specific linear regression models were used to assess the association between SD increase in neck circumference and cardiovascular disease (CVD) risk factors (systolic and diastolic blood pressure; total, low-density lipoprotein, and high-density lipoprotein cholesterol and triglycerides; and fasting plasma glucose, insulin, proinsulin, and homeostasis model assessment of insulin resistance). Neck circumference was correlated with VAT [r = 0.63 (men); r = 0.74 (women); P < 0.001] and BMI [r = 0.79 (men); r = 0.80 (women); P < 0.001]. After further adjustment for VAT, neck circumference was positively associated with systolic blood pressure, diastolic blood pressure in men only, triglycerides, fasting plasma glucose in women only, insulin, proinsulin, and homeostasis model assessment of insulin resistance and was inversely associated with high-density lipoprotein (all P values < 0.01). Similar results were observed in models that adjusted for both VAT and BMI. In a secondary analysis of incident CVD as an outcome, there was no statistically significant association observed for neck circumference in multivariable-adjusted models.Conclusions: Neck circumference is associated with CVD risk factors even after adjustment for VAT and BMI. These findings suggest that upper-body sc fat may be a unique, pathogenic fat depot. (J Clin Endocrinol Metab 95: 3701-3710, 2010)