Birth weight; postnatal, infant, and childhood growth; and obesity in young adulthood: evidence from the Barry Caerphilly Growth Study
Birth weight; postnatal, infant, and childhood growth; and obesity in young adulthood: evidence from the Barry Caerphilly Growth Study
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DOI：
10.1093/ajcn/86.4.907
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发表时间：
2007-10-01
影响因子：
7.1
通讯作者：
Ben-Shlomo, Yoav
中科院分区：
文献类型：
--
作者：
McCarthy, Anne;Hughes, Rachael;Ben-Shlomo, Yoav
背景：出生体重与成人肥胖呈正相关，但相对较少的研究考察了儿童早期特定时期的生长与生长的关系。目的：目的：评估出生到5岁之间的生长指标与成人肥胖指标的相关性。设计：我们对英国巴里和卡菲利的年轻人进行了一项纵向研究，他们之前曾在1972至1974年间参加过一项补充牛奶的随机对照试验。我们重新检查了679名男性和女性(占目标人口的72%)，测量了体重指数(BMI；单位为kg/m(2))、腰臀比、矢状腹直径和腰围。结果：体重速度从1岁和9个月到5岁的增长是BMI、腰围和矢状腹直径最重要的预测因素。在此期间，体重增加的z分数增加与体重指数增加1.13%相关(95%可信区间：0.69，1.57；P<；0.001)。婴儿出生后5个月和9个月体重增加对腰臀比的预测作用最强(0.51；95%CI：0.00，1.02；P=0.05)。结论：出生体重不能根据儿童时期的体重增加来预测肥胖。成人肥胖和不同时期体重增加之间的联系是不同的，这取决于所使用的肥胖衡量标准。儿童早期是否是成人肥胖初级预防的最佳时期，目前尚不清楚。
Background: Birth weight has been shown to be positively associated with adult obesity, but relatively few studies have examined the associations with growth in specific periods of early childhood.Objective: The objective was to assess the association of measures of growth between birth and 5 y of age with adult measures of adiposity.Design: We conducted a longitudinal study of young adults from Barry and Caerphilly, United Kingdom, who had previously taken part between 1972 and 1974 in a randomized controlled trial of milk supplementation. We reexamined 679 men and women (72% of the target population) to measure body mass index (BMI; in kg/m(2)), waist-to-hip ratio, sagittal abdominal diameter, and waist circumference.Results: An increase in weight velocity from 1 y and 9 mo to 5 y of age was the most important predictor of BMI, waist circumference, and sagittal abdominal diameter. A z-score increase in weight gain in this period was associated with an increase in BMI of 1.13 (95% CI: 0.69,1.57; P < 0.001). Infant weight gain from 5 mo to I y and 9 mo was the strongest predictor of waist-to-hip ratio (0.51; 95% CI: 0.00, 1.02; P = 0.05).Conclusions: Birth weight does not predict adiposity on the basis of weight gain in childhood. The association between adult adiposity and weight gain in different periods is variable and depends on the measure of adiposity that is used. It remains unclear whether early childhood is the optimum period in the life course for the primary prevention of adult adiposity.