Undescribed toxin in pseudomembranous colitis.
Undescribed toxin in pseudomembranous colitis.
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伪膜性结肠炎中未描述的毒素。
DOI：
10.1136/bmj.1.6071.1246
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发表时间：
1977
影响因子：
--
通讯作者：
D. Tyrrell
中科院分区：
文献类型：
--
作者：
H. Larson;J. Parry;A. Price;D. Davies;J. Dolby;D. Tyrrell
一个12岁的女孩在短期口服青霉素后发生了伪膜性结肠炎。患者在发病前后均无青霉素不良反应史。在她的粪便中没有发现致病细菌，支原体或病毒，但它们确实含有毒素。毒素也被发现在四个其他五例伪膜性结肠炎，但没有在六个标本从其他疾病引起的腹泻患者。进一步的研究可能表明，伪膜性结肠炎是由细菌毒素引起的。
A girl aged 12 developed pseudomembranous colitis after a short course of oral penicillin. She had no history of adverse reaction to penicillin before or after the illness. No pathogenic bacteria, mycoplasmas, or viruses were found in her faeces, but they did contain a toxin. Toxin was also found in four of five other patients with pseudomembranous colitis but not in six specimens obtained from patients with diarrhoea caused by other disorders. Further studies may show that pseudomembranous colitis is caused by a bacterial toxin.