The Effect of Acute Intraocular Pressure Elevation on Peripapillary Retinal Thickness, Retinal Nerve Fiber Layer Thickness, and Retardance
The Effect of Acute Intraocular Pressure Elevation on Peripapillary Retinal Thickness, Retinal Nerve Fiber Layer Thickness, and Retardance
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DOI：
10.1167/iovs.08-3289
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发表时间：
2009-10-01
影响因子：
4.4
通讯作者：
Burgoyne, Claude F.
中科院分区：
文献类型：
--
作者：
Fortune, Brad;Yang, Hongli;Burgoyne, Claude F.
目的。为了确定急性升高的眼压是否会改变视网膜乳头周围厚度、视网膜神经纤维层厚度(RNFLT)或阻滞性。方法：在异氟醚麻醉下，对9个成年非人灵长类动物进行研究。在眼压设定为10 mm Hg后30min和眼压设定为45 mm Hg后60min用光谱域光学相干断层扫描测量视网膜和RNFLT。在眼压为10 mm Hg时，每隔10分钟扫描激光偏振仪测量RNFL延迟30min，然后在眼压为45 mm Hg时扫描激光偏振仪测量RNFL延迟60min，然后在眼压恢复到10 mm Hg时测量RNFL延迟30min。结果：RNFLT在眼压为10 mm Hg时测量了1120 mm m，从10 mm Hg时的118.1±9.3 mm m减小到45 mm Hg时的116.5±8.4m m，降幅为1.4%/-1.8%(P<；0.0001)。眼压和偏心率之间存在显著的交互作用(P<；0.0006)。眼压升高60分钟后，眼压升高至45 mm Hg时，眼压升高至45 mm Hg时，眼底神经纤维层变薄4.9%+/-3.4%(P<；0.001)，偏斜度较大者无明显变化。视网膜厚度也观察到了同样的模式，在45 mm Hg时，视网膜总体变薄了1.1%+/-0.8%(P<；0.0001)，偏心效应显著(P<；0.0001)，在800微米范围内视网膜变薄了4.8%+/-1.2%(P<；0.001)，但在那之后没有变化。眼压升高至45 mm Hg(P=0.0031)60min后，眼压升高对视网膜厚度、视网膜神经纤维层厚度及眼压延迟性的影响较小，仅限于眼底周围，不太可能对临床产生有意义的影响。(投资眼科VS科学。2009年；50：4719-4726)doi：10.1167/iovs.08-3289
PURPOSE. To determine whether acutely elevated intraocular pressure (IOP) alters peripapillary retinal thickness, retinal nerve fiber layer thickness (RNFLT), or retardance.METHODS. Nine adult nonhuman primates were studied while under isoflurane anesthesia. Retinal and RNFLTs were measured by spectral domain optical coherence tomography 30 minutes after IOP was set to 10 mm Hg and 60 minutes after IOP was set to 45 mm Hg. RNFL retardance was measured by scanning laser polarimetry in 10-minute intervals for 30 minutes while IOP was 10 mm Hg, then for 60 minutes while IOP was 45 mm Hg, then for another 30 minutes after IOP was returned to 10 mm Hg.RESULTS. RNFLT measured 1120 mu m from the ONH center decreased from 118.1 +/- 9.3 mu m at an IOP of 10 mm Hg to 116.5 +/- 8.4 mu m at 45 mm Hg, or by 1.4% +/- 1.8% (P < 0.0001). There was a significant interaction between IOP and eccentricity (P < 0.0006). Within 800 mu m of the ONH center, the RNFL was 4.9% +/- 3.4% thinner 60 minutes after IOP elevation to 45 mm Hg (P < 0.001), but unchanged for larger eccentricities. The same pattern was observed for retinal thickness, with 1.1% +/- 0.8% thinning overall at 45 mm Hg (P < 0.0001), and a significant effect of eccentricity (P < 0.0001) whereby the retina was 4.8% +/- 1.2% thinner (P < 0.001) within 800 mu m, but unchanged beyond that. Retardance increased by a maximum of 2.2% +/- 1.1% 60 minutes after IOP was increased to 45 mm Hg (P = 0.0031).CONCLUSIONS. The effects of acute IOP elevation on retinal thickness, RNFL thickness and retardance were minor, limited to the immediate ONH surround and unlikely to have meaningful clinical impact. (Invest Ophthalmol Vis Sci. 2009;50: 4719-4726) DOI: 10.1167/iovs.08-3289