A longitudinal study of auditory evoked field and language development in young children
A longitudinal study of auditory evoked field and language development in young children
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幼儿听觉诱发场与语言发展的纵向研究
DOI：
10.1016/j.neuroimage.2014.07.034
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发表时间：
2014
期刊：
影响因子：
5.7
通讯作者：
Minabe Yoshio
中科院分区：
文献类型：
--
作者：
Yoshimura Yuko;Kikuchi Mitsuru;Ueno Sanae;Shitamichi Kiyomi;Remijn Gerard;Hiraishi Hirotoshi;Hasegawa Chiaki;Furutani Naoki;Oi Manabu;Munesue Toshio;Tsubokawa Tunehisa;Higashida Haruhiro;Minabe Yoshio
儿童早期语言发展和与人类声音相关的大脑功能成熟之间的关系仍然不清楚。由于听觉系统的发育可能与幼儿的语言发育相关，我们采用纵向设计，使用无创儿童定制脑磁图（MEG）研究了听觉诱发场（AEF）与语言发育之间的关系。招募了20名发育正常的儿童（第一次测量时年龄为36-75个月）。这些儿童在第一次测量后11-25个月进行了重新调查。AEF成分P1 m进行了检查，以调查每个参与者的神经大脑对声音刺激的反应的发展变化。此外，我们还研究了大脑反应和语言表现之间的关系。第二次测量时，与第一次测量相比，两个半球对声音刺激的P1 m峰值幅度显著增加。但P1 m潜伏期无差异。值得注意的是，我们的研究结果表明，左半球P1 m振幅增加较大的儿童在语言测试中表现更好。因此，我们的研究结果表明，P1 m诱发的声音刺激是一个神经生理标记的语言发展的幼儿。此外，MEG是一种可用于基于幼儿听觉诱发场来研究听觉皮层成熟的技术。本研究首次证明了幼儿听觉加工系统的发展与语言能力的发展之间的重要关系。
The relationship between language development in early childhood and the maturation of brain functions related to the human voice remains unclear. Because the development of the auditory system likely correlates with language development in young children, we investigated the relationship between the auditory evoked field (AEF) and language development using non-invasive child-customized magnetoencephalography (MEG) in a longitudinal design.Twenty typically developing children were recruited (aged 36–75 months old at the first measurement). These children were re-investigated 11–25 months after the first measurement. The AEF component P1m was examined to investigate the developmental changes in each participant's neural brain response to vocal stimuli. In addition, we examined the relationships between brain responses and language performance. P1m peak amplitude in response to vocal stimuli significantly increased in both hemispheres in the second measurement compared to the first measurement. However, no differences were observed in P1m latency. Notably, our results reveal that children with greater increases in P1m amplitude in the left hemisphere performed better on linguistic tests. Thus, our results indicate that P1m evoked by vocal stimuli is a neurophysiological marker for language development in young children. Additionally, MEG is a technique that can be used to investigate the maturation of the auditory cortex based on auditory evoked fields in young children. This study is the first to demonstrate a significant relationship between the development of the auditory processing system and the development of language abilities in young children.