Temporal and spatial dynamics of scaling-specific features of a gene regulatory network in Drosophila.
Temporal and spatial dynamics of scaling-specific features of a gene regulatory network in Drosophila.
复制标题
果蝇基因调控网络特定尺度特征的时空动态。
DOI：
10.1038/ncomms10031
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发表时间：
2015
影响因子：
16.6
通讯作者：
Ma,Jun
中科院分区：
文献类型：
--
作者：
Wu,Honggang;Manu;Jiao,Renjie;Ma,Jun
发育稳健性的一个广为人知的方面是与大小成比例的模式形成。但这种缩放功能是如何动态出现的仍然知之甚少。在这里，我们生成了果蝇黑腹胚胎中六个大小差异显着的间隙基因表达谱的数据集。表达模式在空间和时间上表现出大小依赖性动态。我们发现后部鳞片缩小的动态出现，伴随着大胚胎中部附近间隙基因表达水平的降低。模拟结果表明，大小相关的 Bicoid 梯度输入可以导致 Krüppel 表达减少，从而对后部间隙基因表达产生远程和动态影响。因此，对于尺度模式的出现，整个胚胎可以被视为一个统一的动态系统，其中本地解释的母体衍生的大小依赖信息可以在基因调控网络的动态控制下在空间和时间上传播。
A widely appreciated aspect of developmental robustness is pattern formation in proportion to size. But how such scaling features emerge dynamically remains poorly understood. Here we generate a data set of the expression profiles of six gap genes inDrosophila melanogasterembryos that differ significantly in size. Expression patterns exhibit size-dependent dynamics both spatially and temporally. We uncover a dynamic emergence of under-scaling in the posterior, accompanied by reduced expression levels of gap genes near the middle of large embryos. Simulation results show that a size-dependent Bicoid gradient input can lead to reducedKrüppelexpression that can have long-range and dynamic effects on gap gene expression in the posterior. Thus, for emergence of scaled patterns, the entire embryo may be viewed as a single unified dynamic system where maternally derived size-dependent information interpreted locally can be propagated in space and time as governed by the dynamics of a gene regulatory network.