Family history and socioeconomic risk factors for non-syndromic cleft lip and palate: A matched case-control study in a less developed country
Family history and socioeconomic risk factors for non-syndromic cleft lip and palate: A matched case-control study in a less developed country
复制标题
DOI：
10.1590/s0120-41572011000300010
复制
发表时间：
2011-09-01
期刊：
影响因子：
--
通讯作者：
Villalobos-Rodelo, Juan J
中科院分区：
文献类型：
--
作者：
Acuña-González, Gladys;Medina-Solís, Carlo E;Villalobos-Rodelo, Juan J
介绍。从流行病学的角度来看，非综合征性口颌面裂是世界范围内最常见的口腔先天性畸形。 目的。追踪家族史并确定伴有或不伴有腭裂的非综合征性唇裂的社会经济危险因素。材料和方法。对 208 例伴有或不伴有腭裂的非综合征性唇裂病例进行了病例对照研究，并与 416 名对照者按年龄和性别进行匹配。病例是 2002 年至 2004 年在墨西哥坎佩切转诊诊所就诊的患者。通过问卷调查收集社会人口统计学和社会经济变量以及与非综合征性唇裂（伴或不伴腭裂）相关的家庭背景。使用条件逻辑回归模型；计算调整后的比值比和 95% 置信区间。结果。在多变量模型中，确定了以下风险因素：1）社会经济地位低； 2）出生于坎佩切州南部地区； 3) 上门分娩或公立医院分娩； 4) 父亲或母亲家族中曾出现过非综合征性唇裂伴或不伴腭裂病例； 5) 有兄弟姐妹患有非综合征性唇裂伴或不伴腭裂； 6)先证者有其他畸形，7)妊娠期间有感染史。包括补充维生素在内的产前护理是伴有或不伴有腭裂的非综合征性唇裂的保护因素（比值比=0.29）。结论。人们认为“健康的社会梯度”将口腔畸形与饮食成分以及低社会经济地位广泛涵盖的一些社会经济和社会人口因素联系起来。风险因素的进一步描述将指导为有非综合征性唇裂和腭裂风险的家庭制定积极的咨询和预防计划。
Introduction. From an epidemiological point of view, non-syndromic orofacial clefts are the most common oral congenital deformities worldwide.Objective. Family histories were traced and socioeconomic risk factors were identified for non-syndromic cleft lip with or without cleft palate.Material and methods. A case-control study was carried out with 208 cases of non-syndromic cleft lip with or without cleft palate, and matched by age and sex with 416 controls. Cases were patients attending a referral clinic from 2002 through 2004 in Campeche, Mexico. A questionnaire was administered to collect sociodemographic and socioeconomic variables as well as familial background relevant to non-syndromic cleft lip with or without cleft palate. Conditional logistic regression models were used; adjusted odds ratios and 95% confidence intervals were calculated.Results. In the multivariate model, the following risk factors were identified: 1) low socioeconomic status; 2) birth in the southern region of Campeche state; 3) home delivery or delivery in a publicly funded hospital; 4) occurrence of prior non-syndromic cleft lip with or without cleft palate cases in the father's or mother's family: 5) having a sibling with non-syndromic cleft lip with or without cleft palate; 6) the proband having another malformation, and 7) a history of infections during pregnancy. Prenatal care consisting of vitamin supplementation was a protective factor for non-syndromic cleft lip with or without cleft palate (odds ratio=0.29).Conclusions. A "social gradient in health" was seen to link oral malformation with diet components, and several socioeconomic and socio-demographic factors broadly encompassed in low socioeconomic status. Further characterization of risk factors will guide the assemblage of a pro-active counseling and prevention program for families at risk for non-syndromic cleft lip and cleft palate.