Viral mimicry of the complement system.
Viral mimicry of the complement system.
复制标题
补体系统的病毒模仿。
DOI：
10.1007/bf02970145
复制
发表时间：
2003-04
影响因子：
2.9
通讯作者：
Sahu A
中科院分区：
文献类型：
--
作者：
Bernet J;Mullick J;Singh AK;Sahu A
补体系统是一种有效的先天免疫机制，由旨在对抗和消除所有外来病原体入侵的蛋白质级联组成。尽管病毒体积较小，结构相对简单，但它们对补体攻击并不免疫。因此，补体系统的激活可导致无细胞病毒的中和、C3 b包被的病毒颗粒的吞噬、病毒感染细胞的裂解以及炎症和特异性免疫应答的产生。然而，为了对抗宿主反应并作为病原体成功，病毒不仅开发/采用了控制补体的机制，而且还将这些相互作用转化为自身优势。重要的实例包括痘病毒、疱疹病毒、逆转录病毒、副粘病毒和小核糖核酸病毒。在这篇综述中，我们提供了各种补体逃避策略的信息，病毒已经开发出挫败补体攻击的主机。特别强调的是在分子模拟和补体系统中涉及的病毒蛋白质之间的相互作用。
The complement system is a potent innate immune mechanism consisting of cascades of proteins which are designed to fight against and annul intrusion of all the foreign pathogens. Although viruses are smaller in size and have relatively simple structure, they are not immune to complement attack. Thus, activation of the complement system can lead to neutralization of cell-free viruses, phagocytosis of C3b-coated viral particles, lysis of virus-infected cells, and generation of inflammatory and specific immune responses. However, to combat host responses and succeed as pathogens, viruses not only have developed/adopted mechanisms to control complement, but also have turned these interactions to their own advantage. Important examples include poxviruses, herpesviruses, retroviruses, paramyxoviruses and picornaviruses. In this review, we provide information on the various complement evasion strategies that viruses have developed to thwart the complement attack of the host. A special emphasis is given on the interactions between the viral proteins that are involved in molecular mimicry and the complement system.