Ultrastructural Localization of Pemphigus Autoantibodies within the Epidermis
Ultrastructural Localization of Pemphigus Autoantibodies within the Epidermis
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表皮内天疱疮自身抗体的超微结构定位
DOI：
10.1038/229059a0
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发表时间：
1971
期刊：
影响因子：
64.8
通讯作者：
E. Schreiner
中科院分区：
文献类型：
--
作者：
K. Wolff;E. Schreiner
间接免疫荧光技术显示，寻常型天疱疮患者的血清中含有免疫球蛋白(Ig G)，它与复层扁平上皮细胞间隙的假定位置1-3特异性结合。这些诊断抗体的滴度反映了疾病的进展以及患者对治疗的反应。有相当多的证据表明，细胞间隙中发现的免疫球蛋白1、5和补体6代表自身抗体4。这些数据表明，免疫球蛋白沉积的分布与本病的原发病变相对应。
INDIRECT immunofluorescent techniques show that the sera of patients with pemphigus vulgaris contain immunoglobulins (IgG) which specifically bind to the presumed site of the intercellular space of stratified squamous epithelia1–3. Pretitres of these diagnostic antibodies reflect the progress of the disease as well as the patient's response to treatment4. There is considerable evidence that the IgG immunoglobulins1,5 and complement6 found in the intercellular spaces represent autoantibodies4. These data imply that the distribution of the IgG deposits corresponds to the primary lesion in this disease7,8.