EFFETTI DELLA TERAPIA ORMONALE SOSTITUTIVA SULLA FUNZIONALITA OCULARE IN POSTMENOPAUSA
EFFETTI DELLA TERAPIA ORMONALE SOSTITUTIVA SULLA FUNZIONALITA OCULARE IN POSTMENOPAUSA
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绝经后的 EFFETTI DELLA TERAPIA ORMONALE SOSTITUTIVA SULLA FUNZIONALITA OCULARE
DOI：
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发表时间：
1998
期刊：
影响因子：
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通讯作者：
C. Nappi
中科院分区：
文献类型：
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作者：
C. Sorrentino;P. Affinito;F. Raso;M. Loffredo;P. Merlino;A. Loffredo;S. Palomba;C. Nappi
目的探讨激素替代疗法(HRT)对绝经后妇女各种眼部参数和症状的影响。设计前瞻性研究。单位：那不勒斯费德里科二世大学妇产科。研究对象14名健康女性口服马匹结合雌激素(0.625 mg/d)和醋酸-甲羟孕酮(10 mg/d)，从第17天到第28天，共3个月。测量眼部症状、眼压(IOP)、泪液分泌量、眼底厚度和角膜厚度。结果术后3个月眼压下降10.8%(p<；0.005)，泪液反射性和基底性分别增加19%和48%，角膜厚度增加16.6%。结论HRT对眼生理有积极作用。
OBJECTIVE Determination of the effects of hormonal replacement therapy (HRT) on various ocular parameters and symptoms in postmenopausal women. DESIGN Prospective study. SETTING Department of Obstetrics and Gynecology, University "Federico II" of Naples. PATIENTS 14 healthy women treated orally with equine conjugated estrogen in continuous (0,625 mg/daily) and acetate-medroxyprogesteron (10 mg/daily) from 17th to 28th day for three months. MEASURES Ocular symptomatology, intraocular pressure (IOP), lacrimal secretion, reflected and basal and corneal thickness. RESULTS After 3 months of HRT the IOP was reduced of 10.8% (p < 0.005), the lacrimal secretion, reflected and basal, increased of 19% and 48%, respectively and the corneal thickness increased of 16.6%. CONCLUSION The HRT has a positive effect on ocular physiology.