SELECTIVE IMMUNOTOXIC LESIONS OF BASAL FOREBRAIN CHOLINERGIC CELLS - EFFECTS ON LEARNING AND MEMORY IN RATS
SELECTIVE IMMUNOTOXIC LESIONS OF BASAL FOREBRAIN CHOLINERGIC CELLS - EFFECTS ON LEARNING AND MEMORY IN RATS
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DOI：
10.1037/0735-7044.109.4.714
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发表时间：
1995-08-01
影响因子：
1.9
通讯作者：
GALLAGHER, M
中科院分区：
文献类型：
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作者：
BAXTER, MG;BUCCI, DJ;GALLAGHER, M
雄性Long-Evans大鼠注射192 IgG-皂草素（一种对基底前脑胆碱能神经元（LES）具有明显选择性的毒素）或溶媒（CON）至内侧隔和斜角带垂直支（MS/VDB）或双侧基底核大细胞和无名质（nBM/SI）。在Morris水迷宫中的位置辨别评估了空间学习，并且在水迷宫中的试验独特的匹配位置任务评估了在不同延迟下对位置信息的记忆。MS/VDB-LES和nBM/SI-LES大鼠相对于CON大鼠在位置辨别的获取中没有受损，但相对于CON大鼠在记忆任务的执行中即使在最短的延迟中也轻度受损，这表明非记忆缺陷。这些结果与较少选择性病变的影响形成对比，后者已被用于支持基底前脑胆碱能神经元在学习和记忆中的作用。
Male Long-Evans rats were given injections of either 192 IgG-saporin, an apparently selective toxin for basal forebrain cholinergic neurons (LES), or vehicle (CON) into either the medial septum and vertical limb of the diagonal band (MS/VDB) or bilaterally into the nucleus basalis magnocellularis and substantia innominata (nBM/SI). Place discrimination in the Morris water maze assessed spatial learning, and a trial-unique matching-to-place task in the water maze assessed memory for place information over varying delays. MS/VDB-LES and nBM/SI-LES rats were not impaired relative to CON rats in acquisition of the place discrimination, but were mildly impaired relative to CON rats in performance of the memory task even at the shortest delay, suggesting a nonmnemonic deficit. These results contrast with effects of less selective lesions, which have been taken to support a role for basal forebrain cholinergic neurons in learning and memory.