Information and communication technology in biodesign and component characterisation
Information and communication technology in biodesign and component characterisation
复制标题
生物设计和成分表征中的信息和通信技术
DOI：
10.1049/cp.2016.1239
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Kitney R
中科院分区：
文献类型：
--
作者：
Kitney R
合成生物学/生物工程学的一个迅速发展的领域是信息和通信技术的使用。一个重要原因是越来越多的实验室自动化的使用。在过去的几年里，单个液体处理机器人在湿实验室中变得普遍。然而，在合成生物学中，驱动力是朝着大大提高可靠性和可重复性的方向发展。这对工业翻译来说至关重要。因此，有必要开发基于网络的信息系统和新的技术标准。在这方面，SynBIS和DICOMSB分别代表了信息系统和技术标准的重大发展。已经认识到，使用单独的液体处理机器人等不足以作为实现所需水平的可靠性、再现性和误差的方法。因此，这导致了DNA铸造厂的发展。在我们的例子中，DNA铸造厂形成了由信息基础设施集成的整体基础设施的一部分。这使得能够以大规模并行模式进行表征实验-同时能够减少错误并显着提高可靠性和再现性。
A rapidly developing area of synthetic biology/ engineering of biology is the use of information and communication technology (ICT). An important reason for this is the use of more and more laboratory automation. Over the past few years individual liquid handling robots have become prevalent in wet labs. However, in synthetic biology the drive is towards vastly improved reliability and reproducibility. This is vital for industrial translation. Consequently, there has been a need to develop web-based information systems and new technical standards. In this regard, SynBIS and DICOMSB represent significant developments in information systems and technical standards, respectively. It has been recognised that the use of individual liquid handling robots etc. is inadequate as an approach to achieving the required levels of reliability, reproducibility and errors. Consequently, this has resulted in the development of DNA foundries. In our case the DNA foundry forms part of an overall infrastructure which is integrated by an information infrastructure. This has resulted in the ability to undertake characterisation experiments in a massively parallel mode - with the concomitant ability to reduce errors and a significant increase in reliability and reproducibility.